Photolability of bleomycin and its complexes

Nutan Thakrar; Kenneth Thomas Douglas

doi:10.1016/0304-3835(81)90027-6

Photolability of bleomycin and its complexes

Nutan Thakrar^*, Kenneth Thomas Douglas

^*Corresponding author for this work

Pharmacy

The University of Essex

Research output: Contribution to journal › Letter › peer-review

Abstract

Bleomycin has been found to be very sensitive to photolysis and on irradiation with the full spectral range of a medium-pressure mercury lamp undergoes a number of photo-induced reactions; there is a process in which the absorbance at 310 nm decreases, and a slower process in which it increases with photolysis time. The faster process can be studied by irradiation at ∼ 300-350 nm, is complete in ∼ 8 min, obeys first order kinetics, but is itself biphasic. The Fe(II) and Cu(II) complexes of bleomycin are also photolabile, as is the bleomycin-DNA complex.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	Cancer Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(81)90027-6
Publication status	Published - Aug 1981

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AU - Douglas, Kenneth Thomas

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AB - Bleomycin has been found to be very sensitive to photolysis and on irradiation with the full spectral range of a medium-pressure mercury lamp undergoes a number of photo-induced reactions; there is a process in which the absorbance at 310 nm decreases, and a slower process in which it increases with photolysis time. The faster process can be studied by irradiation at ∼ 300-350 nm, is complete in ∼ 8 min, obeys first order kinetics, but is itself biphasic. The Fe(II) and Cu(II) complexes of bleomycin are also photolabile, as is the bleomycin-DNA complex.

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DO - 10.1016/0304-3835(81)90027-6

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JO - Cancer Letters

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Photolability of bleomycin and its complexes

Abstract

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