Photoredox Synthesis of Aryl-Hydroxylamines from Carboxylic Acids and Nitrosoarenes

Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here, we demonstrate the direct conversion of carboxylic acids into the corresponding alkyl hydroxylamines using organo-photoredox catalysis. The process relies in the generation of alkyl radicals via photo-induced oxidation–decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in novel radical cascade processes.