Physical mapping of the NF2/meningioma region on human chromosome 22q12

M. H. Ruttledge; Y. G. Xie; F. Y. Han; M. Giovannini; M. Janson; I. Fransson; B. Werelius; O. Delattre; G. Thomas; G. Evans; J. P. Dumanski

doi:10.1006/geno.1994.1012

Physical mapping of the NF2/meningioma region on human chromosome 22q12

M. H. Ruttledge, Y. G. Xie, F. Y. Han, M. Giovannini, M. Janson, I. Fransson, B. Werelius, O. Delattre, G. Thomas, G. Evans, J. P. Dumanski

Research output: Contribution to journal › Article › peer-review

Abstract

Loss of genetic information from chromosome 22 has been implicated in the development of neurofibromatosis type 2, meningioma, and several other neoplasia. Molecular studies indicate that genes within chromosomal band 22q12 may be involved in tumorigenesis. We have mapped 29 loci into 16 groups in this region, using pulsed-field gel electrophoresis, fluorescence in situ suppression hybridization, and somatic cell hybrid mapping. The region spans more than 5 Mb of genomic DNA and contains the genes for neurofibromatosis type 2 and meningioma. The order of loci presented here provides the framework for the fine mapping of this region using cosmids and yeast artificial chromosomes, and it facilitates the speedy cloning of novel genes from 22q12.

Original language	English
Pages (from-to)	52-59
Number of pages	7
Journal	Genomics
Volume	19
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1012
Publication status	Published - 1994

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title = "Physical mapping of the NF2/meningioma region on human chromosome 22q12",

abstract = "Loss of genetic information from chromosome 22 has been implicated in the development of neurofibromatosis type 2, meningioma, and several other neoplasia. Molecular studies indicate that genes within chromosomal band 22q12 may be involved in tumorigenesis. We have mapped 29 loci into 16 groups in this region, using pulsed-field gel electrophoresis, fluorescence in situ suppression hybridization, and somatic cell hybrid mapping. The region spans more than 5 Mb of genomic DNA and contains the genes for neurofibromatosis type 2 and meningioma. The order of loci presented here provides the framework for the fine mapping of this region using cosmids and yeast artificial chromosomes, and it facilitates the speedy cloning of novel genes from 22q12.",

author = "Ruttledge, {M. H.} and Xie, {Y. G.} and Han, {F. Y.} and M. Giovannini and M. Janson and I. Fransson and B. Werelius and O. Delattre and G. Thomas and G. Evans and Dumanski, {J. P.}",

year = "1994",

doi = "10.1006/geno.1994.1012",

language = "English",

volume = "19",

pages = "52--59",

journal = "Genomics",

issn = "0888-7543",

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TY - JOUR

T1 - Physical mapping of the NF2/meningioma region on human chromosome 22q12

AU - Ruttledge, M. H.

AU - Xie, Y. G.

AU - Han, F. Y.

AU - Giovannini, M.

AU - Janson, M.

AU - Fransson, I.

AU - Werelius, B.

AU - Delattre, O.

AU - Thomas, G.

AU - Evans, G.

AU - Dumanski, J. P.

PY - 1994

Y1 - 1994

N2 - Loss of genetic information from chromosome 22 has been implicated in the development of neurofibromatosis type 2, meningioma, and several other neoplasia. Molecular studies indicate that genes within chromosomal band 22q12 may be involved in tumorigenesis. We have mapped 29 loci into 16 groups in this region, using pulsed-field gel electrophoresis, fluorescence in situ suppression hybridization, and somatic cell hybrid mapping. The region spans more than 5 Mb of genomic DNA and contains the genes for neurofibromatosis type 2 and meningioma. The order of loci presented here provides the framework for the fine mapping of this region using cosmids and yeast artificial chromosomes, and it facilitates the speedy cloning of novel genes from 22q12.

AB - Loss of genetic information from chromosome 22 has been implicated in the development of neurofibromatosis type 2, meningioma, and several other neoplasia. Molecular studies indicate that genes within chromosomal band 22q12 may be involved in tumorigenesis. We have mapped 29 loci into 16 groups in this region, using pulsed-field gel electrophoresis, fluorescence in situ suppression hybridization, and somatic cell hybrid mapping. The region spans more than 5 Mb of genomic DNA and contains the genes for neurofibromatosis type 2 and meningioma. The order of loci presented here provides the framework for the fine mapping of this region using cosmids and yeast artificial chromosomes, and it facilitates the speedy cloning of novel genes from 22q12.

U2 - 10.1006/geno.1994.1012

DO - 10.1006/geno.1994.1012

M3 - Article

C2 - 8188242

SN - 0888-7543

VL - 19

SP - 52

EP - 59

JO - Genomics

JF - Genomics

IS - 1

ER -

Physical mapping of the NF2/meningioma region on human chromosome 22q12

Abstract

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