Physico-chemical characteristics of coated silicone textured versus smooth breast implants differentially influence breast-derived fibroblast morphology and behaviour

Anai A. Valencia-Lazcano, Teresa Alonso-Rasgado, Ardeshir Bayat

    Research output: Contribution to journalArticlepeer-review

    Abstract

    © 2014 Elsevier Ltd.Capsule formation is an inevitable consequence of silicone breast implantation. Clinically challenging dense fibrocollagenous capsular contractures occur at different rates between smooth compared to textured surfaces. Host response is influenced by several factors including implant surface texture, chemistry and interactions between cells and the extracellular matrix (ECM). Specific coatings can modify the physico-chemical properties of implant surfaces eliciting specific cellular reactions. Therefore, we evaluated the physico-chemical characteristics of coated smooth versus textured silicone breast implants on breast-derived fibroblast morphology and behaviour using (a) confocal laser microscopy, (b) Raman spectroscopy and (c) the effect of four unique protein and glycosaminoglycan (GAG) coatings (aggrecan, collagen I, fibronectin and hyaluronic acid) on breast-derived fibroblast attachment, proliferation, morphology, spreading, cytotoxicity and gene expression. Collagen I, fibronectin and hyaluronic acid coatings exhibited satisfactory fibroblast adhesion (p
    Original languageEnglish
    Pages (from-to)140-155
    Number of pages15
    JournalJournal of the mechanical behavior of biomedical materials
    Volume40
    DOIs
    Publication statusPublished - 3 Sep 2014

    Keywords

    • Adhesion
    • Breast tissue fibroblasts
    • Gene expression
    • Silicone breast implants
    • Specific coatings

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