TY - JOUR
T1 - Physiological and pathological modulation of ryanodinereceptor function in cardiac muscle.
AU - Eisner, DA
AU - Diaz, ME
AU - O'Neill, SC
AU - Trafford, AW.
PY - 2004/6
Y1 - 2004/6
N2 - Calcium release from the sarcoplasmic reticulum (SR) incardiac muscle occurs through a specialised release channel, theryanodine receptor, RyR, via the process of Ca-induced Ca release(CICR).The open probability of the RyR is increased by elevation ofcytoplasmic Ca concentration ([Ca(2+)](i)).However, in addition to Ca, other modulators affect the RyR openprobability.Agents which increase the RyR opening during systole produce atransient increase of systolic [Ca(2+)](i) followed by a return to theinitial level due to a compensating decrease of SR Ca content.Increasing RyR opening during diastole decreases SR Ca content andthereby decreases systolic [Ca(2+)](i).We therefore conclude that potentiation of RyR opening will, ifanything, decrease systolic [Ca(2+)](i).The effects of specific examples of modulators of the RyR, such asphosphorylation, metabolic changes, heart failure and polyunsaturatedfatty acids, are discussed.
AB - Calcium release from the sarcoplasmic reticulum (SR) incardiac muscle occurs through a specialised release channel, theryanodine receptor, RyR, via the process of Ca-induced Ca release(CICR).The open probability of the RyR is increased by elevation ofcytoplasmic Ca concentration ([Ca(2+)](i)).However, in addition to Ca, other modulators affect the RyR openprobability.Agents which increase the RyR opening during systole produce atransient increase of systolic [Ca(2+)](i) followed by a return to theinitial level due to a compensating decrease of SR Ca content.Increasing RyR opening during diastole decreases SR Ca content andthereby decreases systolic [Ca(2+)](i).We therefore conclude that potentiation of RyR opening will, ifanything, decrease systolic [Ca(2+)](i).The effects of specific examples of modulators of the RyR, such asphosphorylation, metabolic changes, heart failure and polyunsaturatedfatty acids, are discussed.
M3 - Article
SN - 0143-4160
VL - 35( 6)
JO - Cell calcium
JF - Cell calcium
ER -