Physiological and pathological modulation of ryanodinereceptor function in cardiac muscle.

DA Eisner, ME Diaz, SC O'Neill, AW. Trafford

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    Calcium release from the sarcoplasmic reticulum (SR) incardiac muscle occurs through a specialised release channel, theryanodine receptor, RyR, via the process of Ca-induced Ca release(CICR).The open probability of the RyR is increased by elevation ofcytoplasmic Ca concentration ([Ca(2+)](i)).However, in addition to Ca, other modulators affect the RyR openprobability.Agents which increase the RyR opening during systole produce atransient increase of systolic [Ca(2+)](i) followed by a return to theinitial level due to a compensating decrease of SR Ca content.Increasing RyR opening during diastole decreases SR Ca content andthereby decreases systolic [Ca(2+)](i).We therefore conclude that potentiation of RyR opening will, ifanything, decrease systolic [Ca(2+)](i).The effects of specific examples of modulators of the RyR, such asphosphorylation, metabolic changes, heart failure and polyunsaturatedfatty acids, are discussed.
    Original languageEnglish
    JournalCell calcium
    Volume35( 6)
    Publication statusPublished - Jun 2004


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