Physiologically Based Pharmacokinetic Modeling of TransporterMediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

D Scotcher, N Melillo, S Tadimalla, AS Darwich, S Ziemian, K Ogungbenro, G Schutz, S Sourbron, A Galetin

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2997-3009
Number of pages13
JournalMolecular Pharmaceutics
Volume18
Issue number8
DOIs
Publication statusPublished - 2 Aug 2021

Keywords

  • Drug transporters
  • Drug-drug interactions
  • Gadoxetate
  • Hepatobiliary excretion
  • Imaging biomarker
  • Physiologically based pharmacokinetic model
  • Quantitative translation

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