Physiologically Based Pharmacokinetic modelling of drug transporters to facilitate individualized dose prediction

Aleksandra Galetin, Ping Zhao, Shiew-Mei Huang

Research output: Contribution to journalArticlepeer-review

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Abstract

Physiologically-based pharmacokinetic (PBPK) modelling is a commonly used strategy in the drug development and regulatory submissions. This commentary provides a critical overview of the current status of PBPK methodologies to predict transporter-mediated pharmacokinetics, in addition to impact of disease and genetics with respect to local and systemic concentration.
Original languageEnglish
Pages (from-to)2204-2208
JournalJournal of Pharmaceutical Sciences
Volume106
Issue number9
Early online date5 Apr 2017
DOIs
Publication statusPublished - 2017

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