Piezoelectric actuator: Searching inspiration in nature for osteoblast stimulation

C. Frias, J. Reis, F. Capela e Silva, J. Potes, J. Simões, A. T. Marques

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Bone is a composite with piezoelectric properties. Bone mass and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels, but the role piezoelectricity plays in bone physiology is yet to be understood. Physical activity enhances bone density, through mechanical stimulation. Osteocytes and osteoblasts are essential for mechanosensing and mechanotransduction. Strategies have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the use of piezoelectric materials as a mean of directly straining bone cells by converse piezoelectric effect. To estimate the magnitude of stress/strain, finite numerical models were applied and theoretical data was complemented by optic experimental data. Osteoblasts were then grown on the surface of the piezoelectric material and cell response studied. © 2010 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)1920-1925
    Number of pages5
    JournalComposites Science and Technology
    Volume70
    Issue number13
    DOIs
    Publication statusPublished - Nov 2010

    Keywords

    • A. Smart material
    • C. Finite element analysis (FEA)
    • C. Stress concentrations
    • Polymeric piezoelectric

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