Pituitary-independent effect of octreotide on IGF1 generation

Ana Pokrajac; Jan Frystyk; Allan Flyvbjerg; Peter J. Trainer

doi:10.1530/EJE-08-0822

Pituitary-independent effect of octreotide on IGF1 generation

Ana Pokrajac
, Jan Frystyk
, Allan Flyvbjerg
, Peter J. Trainer

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Somatostatin analogues are frequently used for medical treatment of acromegaly. The rationale for their use is based on the inhibition of pituitary GH secretion; however, there is in vitro evidence that octreotide also acts to inhibit hepatic IGF1 generation. Aim & design: We studied the pituitary-independent effects of octreotide on IGF1 generation in 11 severely GH-deficient (GHD) humans (age 38, range 23-52; seven males; body mass index 24.7±3 kg/m2; peak-stimulated GH

Original language	English
Pages (from-to)	543-548
Number of pages	5
Journal	European Journal of Endocrinology
Volume	160
Issue number	4
DOIs	https://doi.org/10.1530/EJE-08-0822
Publication status	Published - 2009

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10.1530/EJE-08-0822

http://www.eje-online.org/cgi/reprint/160/4/543

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title = "Pituitary-independent effect of octreotide on IGF1 generation",

abstract = "Background: Somatostatin analogues are frequently used for medical treatment of acromegaly. The rationale for their use is based on the inhibition of pituitary GH secretion; however, there is in vitro evidence that octreotide also acts to inhibit hepatic IGF1 generation. Aim \& design: We studied the pituitary-independent effects of octreotide on IGF1 generation in 11 severely GH-deficient (GHD) humans (age 38, range 23-52; seven males; body mass index 24.7±3 kg/m2; peak-stimulated GH",

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AU - Frystyk, Jan

AU - Flyvbjerg, Allan

AU - Trainer, Peter J.

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N2 - Background: Somatostatin analogues are frequently used for medical treatment of acromegaly. The rationale for their use is based on the inhibition of pituitary GH secretion; however, there is in vitro evidence that octreotide also acts to inhibit hepatic IGF1 generation. Aim & design: We studied the pituitary-independent effects of octreotide on IGF1 generation in 11 severely GH-deficient (GHD) humans (age 38, range 23-52; seven males; body mass index 24.7±3 kg/m2; peak-stimulated GH

AB - Background: Somatostatin analogues are frequently used for medical treatment of acromegaly. The rationale for their use is based on the inhibition of pituitary GH secretion; however, there is in vitro evidence that octreotide also acts to inhibit hepatic IGF1 generation. Aim & design: We studied the pituitary-independent effects of octreotide on IGF1 generation in 11 severely GH-deficient (GHD) humans (age 38, range 23-52; seven males; body mass index 24.7±3 kg/m2; peak-stimulated GH

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DO - 10.1530/EJE-08-0822

M3 - Article

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VL - 160

SP - 543

EP - 548

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

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ER -

Pituitary-independent effect of octreotide on IGF1 generation

Abstract

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