Placental Features of Late-Onset Adverse Pregnancy Outcome.

Lucy E Higgins, Nicolas Rey de Castro, Naa Addo, Mark Wareing, Susan L Greenwood, Rebecca L Jones, Colin P Sibley, Edward D Johnstone, Alexander E P Heazell

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS: Following third trimester presentation with reduced fetal movement (N = 100), placental structure ex vivo was measured. Placental function was then assessed in terms of (i) chorionic plate artery agonist responses and length-tension characteristics using wire myography and (ii) production and release of placentally derived hormones (by quantitative polymerase chain reaction and enzyme linked immunosorbant assay of villous tissue and explant conditioned culture medium). RESULTS: Placentas from pregnancies ending in adverse outcome (N = 23) were ~25% smaller in weight, volume, length, width and disc area (all p
Original languageEnglish
Article numbere0129117
JournalPLoS ONE
Issue number6
Publication statusPublished - 29 Jun 2015


Dive into the research topics of 'Placental Features of Late-Onset Adverse Pregnancy Outcome.'. Together they form a unique fingerprint.

Cite this