Placental Features of Late-Onset Adverse Pregnancy Outcome.

Lucy E Higgins; Nicolas Rey de Castro; Naa Addo; Mark Wareing; Susan L Greenwood; Rebecca L Jones; Colin P Sibley; Edward D Johnstone; Alexander E P Heazell

doi:10.1371/journal.pone.0129117

Placental Features of Late-Onset Adverse Pregnancy Outcome.

Lucy E Higgins, Nicolas Rey de Castro, Naa Addo, Mark Wareing, Susan L Greenwood, Rebecca L Jones, Colin P Sibley, Edward D Johnstone, Alexander E P Heazell

Division of Developmental Biology & Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS: Following third trimester presentation with reduced fetal movement (N = 100), placental structure ex vivo was measured. Placental function was then assessed in terms of (i) chorionic plate artery agonist responses and length-tension characteristics using wire myography and (ii) production and release of placentally derived hormones (by quantitative polymerase chain reaction and enzyme linked immunosorbant assay of villous tissue and explant conditioned culture medium). RESULTS: Placentas from pregnancies ending in adverse outcome (N = 23) were ~25% smaller in weight, volume, length, width and disc area (all p

Original language	English
Article number	e0129117
Journal	PLoS ONE
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0129117
Publication status	Published - 29 Jun 2015

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title = "Placental Features of Late-Onset Adverse Pregnancy Outcome.",

abstract = "OBJECTIVE: Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS: Following third trimester presentation with reduced fetal movement (N = 100), placental structure ex vivo was measured. Placental function was then assessed in terms of (i) chorionic plate artery agonist responses and length-tension characteristics using wire myography and (ii) production and release of placentally derived hormones (by quantitative polymerase chain reaction and enzyme linked immunosorbant assay of villous tissue and explant conditioned culture medium). RESULTS: Placentas from pregnancies ending in adverse outcome (N = 23) were ~25% smaller in weight, volume, length, width and disc area (all p",

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AU - Higgins, Lucy E

AU - Rey de Castro, Nicolas

AU - Addo, Naa

AU - Wareing, Mark

AU - Greenwood, Susan L

AU - Jones, Rebecca L

AU - Sibley, Colin P

AU - Johnstone, Edward D

AU - Heazell, Alexander E P

PY - 2015/6/29

Y1 - 2015/6/29

N2 - OBJECTIVE: Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS: Following third trimester presentation with reduced fetal movement (N = 100), placental structure ex vivo was measured. Placental function was then assessed in terms of (i) chorionic plate artery agonist responses and length-tension characteristics using wire myography and (ii) production and release of placentally derived hormones (by quantitative polymerase chain reaction and enzyme linked immunosorbant assay of villous tissue and explant conditioned culture medium). RESULTS: Placentas from pregnancies ending in adverse outcome (N = 23) were ~25% smaller in weight, volume, length, width and disc area (all p

AB - OBJECTIVE: Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS: Following third trimester presentation with reduced fetal movement (N = 100), placental structure ex vivo was measured. Placental function was then assessed in terms of (i) chorionic plate artery agonist responses and length-tension characteristics using wire myography and (ii) production and release of placentally derived hormones (by quantitative polymerase chain reaction and enzyme linked immunosorbant assay of villous tissue and explant conditioned culture medium). RESULTS: Placentas from pregnancies ending in adverse outcome (N = 23) were ~25% smaller in weight, volume, length, width and disc area (all p

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DO - 10.1371/journal.pone.0129117

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Placental Features of Late-Onset Adverse Pregnancy Outcome.

Abstract

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