Plasma concentrations of arginine vasotocin and urotensin II are reduced following transfer of the euryhaline flounder (Platichthys flesus) from seawater to fresh water

H. Bond, M. J. Winter, J. M. Warne, C. R. McCrohan, R. J. Balment

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Plasma concentrations and stored levels of the neuroendocrine peptides arginine vasotocin (AVT) and urotensin TT (UTT) were measured in the euryhaline flounder (Platichthys flesus) following the acute hypo-osmotic challenge of direct seawater (SW) to fresh water (FW) transfer. Hormone measures, plasma osmolality, and ion concentrations and tissue water content were determined 1, 4, 8, 24, 72, and 144 h after transfer. Plasma AVT concentration fell initially following FW transfer but then returned toward pretransfer levels by day 6. Plasma UII concentration decreased while urophysial UII content was increased following hypo-osmotic challenge relative to SW time-matched controls, suggesting down regulation of the UII system during the initial stages after FW transfer. These changes in neuroendocrine activity were associated with a significant fall in plasma osmolality and major plasma ions. Positive correlations were observed between plasma AVT and osmolality and Cl- and Mg2+ concentrations, suggesting functional association of these plasma parameters with AVT action and/or control of AVT secretion. The initial response to hypotonic challenge involves reduced plasma AVT and UII levels consistent with the proposed role for these hormones, supporting flounder osmoregulation in hypertonic media. © 2002 Elsevier Science (USA).
    Original languageEnglish
    Pages (from-to)113-120
    Number of pages7
    JournalGeneral and comparative endocrinology
    Volume125
    Issue number1
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Arginine vasotocin
    • Fish
    • Neuropeptides
    • Osmoregulation
    • Platichthys flesus
    • Teleost
    • Urotensin II

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