Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.

Linda Gibbons, Sara Rollinson, Jennifer C Thompson, Andrew Robinson, Yvonne S Davidson, Anna Richardson, David Neary, Stuart M Pickering-Brown, Julie S Snowden, David M A Mann

Research output: Contribution to journalArticlepeer-review

Abstract

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.
Original languageEnglish
JournalNeurobiology of Aging
Volume36
Issue number3
DOIs
Publication statusPublished - 18 Oct 2014

Keywords

  • Biomarkers
  • Frontotemporal Lobar degeneration
  • Interleukin-6
  • Progranulin

Research Beacons, Institutes and Platforms

  • Dementia@Manchester

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