PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

Cesare Gargioli, Marcello Coletta, Fabrizio De Grandis, Stefano M. Cannata, Giulio Cossu

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals. © 2008 Nature Publishing Group.
    Original languageEnglish
    Pages (from-to)973-978
    Number of pages5
    JournalNature Medicine
    Volume14
    Issue number9
    DOIs
    Publication statusPublished - Sept 2008

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