PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

Samantha L. McLean; Nagi F. Idris; Ben Grayson; David F. Gendle; Claire MacKie; Anne S. Lesage; Darrel J. Pemberton; Jo C. Neill

doi:10.1177/0269881111431747

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

Samantha L. McLean, Nagi F. Idris, Ben Grayson, David F. Gendle, Claire MacKie, Anne S. Lesage, Darrel J. Pemberton, Jo C. Neill

Research output: Contribution to journal › Article › peer-review

Abstract

The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p <0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p <0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. © 2012 The Author(s).

Original language	English
Pages (from-to)	1265-1270
Number of pages	5
Journal	Journal of Psychopharmacology
Volume	26
Issue number	9
DOIs	https://doi.org/10.1177/0269881111431747
Publication status	Published - Sept 2012

Keywords

α7 nACh receptors
attentional set-shifting
cognition
female rat
phencyclidine
schizophrenia

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10.1177/0269881111431747

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McLean, S. L., Idris, N. F., Grayson, B., Gendle, D. F., MacKie, C., Lesage, A. S., Pemberton, D. J., & Neill, J. C. (2012). PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. Journal of Psychopharmacology, 26(9), 1265-1270. https://doi.org/10.1177/0269881111431747

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title = "PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats",

abstract = "The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p <0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p <0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. {\textcopyright} 2012 The Author(s).",

keywords = "α7 nACh receptors, attentional set-shifting, cognition, female rat, phencyclidine, schizophrenia",

author = "McLean, {Samantha L.} and Idris, {Nagi F.} and Ben Grayson and Gendle, {David F.} and Claire MacKie and Lesage, {Anne S.} and Pemberton, {Darrel J.} and Neill, {Jo C.}",

year = "2012",

month = sep,

doi = "10.1177/0269881111431747",

language = "English",

volume = "26",

pages = "1265--1270",

journal = "Journal of Psychopharmacology",

issn = "1461-7285",

publisher = "Sage Publications Ltd",

number = "9",

}

McLean, SL, Idris, NF, Grayson, B, Gendle, DF, MacKie, C, Lesage, AS, Pemberton, DJ & Neill, JC 2012, 'PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats', Journal of Psychopharmacology, vol. 26, no. 9, pp. 1265-1270. https://doi.org/10.1177/0269881111431747

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. / McLean, Samantha L.; Idris, Nagi F.; Grayson, Ben et al.
In: Journal of Psychopharmacology, Vol. 26, No. 9, 09.2012, p. 1265-1270.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

AU - McLean, Samantha L.

AU - Idris, Nagi F.

AU - Grayson, Ben

AU - Gendle, David F.

AU - MacKie, Claire

AU - Lesage, Anne S.

AU - Pemberton, Darrel J.

AU - Neill, Jo C.

PY - 2012/9

Y1 - 2012/9

N2 - The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p <0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p <0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. © 2012 The Author(s).

AB - The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p <0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p <0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. © 2012 The Author(s).

KW - α7 nACh receptors

KW - attentional set-shifting

KW - cognition

KW - female rat

KW - phencyclidine

KW - schizophrenia

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DO - 10.1177/0269881111431747

M3 - Article

C2 - 22182741

SN - 1461-7285

VL - 26

SP - 1265

EP - 1270

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 9

ER -

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

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Keywords

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