Polo and Aurora kinases - lessons derived from chemical biology

Stephen Taylor; Jan Michael Peters

doi:10.1016/j.ceb.2007.11.008

Polo and Aurora kinases - lessons derived from chemical biology

Research output: Contribution to journal › Article › peer-review

Abstract

During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	77-84
Number of pages	7
Journal	Current opinion in cell biology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.ceb.2007.11.008
Publication status	Published - Feb 2008

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10.1016/j.ceb.2007.11.008

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abstract = "During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

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AB - During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission. © 2007 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.ceb.2007.11.008

M3 - Article

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JO - Current opinion in cell biology

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Polo and Aurora kinases - lessons derived from chemical biology

Abstract

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