Polyamidoamine Starburst® dendrimers as solubility enhancers

O. M. Milhem; C. Myles; N. B. McKeown; D. Attwood; A. D'Emanuele

doi:10.1016/S0378-5173(99)00463-9

Polyamidoamine Starburst® dendrimers as solubility enhancers

O. M. Milhem, C. Myles, N. B. McKeown, D. Attwood, A. D'Emanuele

Research output: Contribution to journal › Article › peer-review

Abstract

The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	239-241
Number of pages	2
Journal	International Journal of Pharmaceutics
Volume	197
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5173(99)00463-9
Publication status	Published - 20 Mar 2000

Keywords

Dendrimers
Ibuprofen
PAMAM G4 dendrimer
Solubility enhancement

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10.1016/S0378-5173(99)00463-9

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title = "Polyamidoamine Starburst{\textregistered} dendrimers as solubility enhancers",

abstract = "The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V.",

keywords = "Dendrimers, Ibuprofen, PAMAM G4 dendrimer, Solubility enhancement",

author = "Milhem, {O. M.} and C. Myles and McKeown, {N. B.} and D. Attwood and A. D'Emanuele",

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doi = "10.1016/S0378-5173(99)00463-9",

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TY - JOUR

T1 - Polyamidoamine Starburst® dendrimers as solubility enhancers

AU - Milhem, O. M.

AU - Myles, C.

AU - McKeown, N. B.

AU - Attwood, D.

AU - D'Emanuele, A.

PY - 2000/3/20

Y1 - 2000/3/20

N2 - The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V.

AB - The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule. (C) 2000 Elsevier Science B.V.

KW - Dendrimers

KW - Ibuprofen

KW - PAMAM G4 dendrimer

KW - Solubility enhancement

U2 - 10.1016/S0378-5173(99)00463-9

DO - 10.1016/S0378-5173(99)00463-9

M3 - Article

SN - 1873-3476

VL - 197

SP - 239

EP - 241

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Polyamidoamine Starburst® dendrimers as solubility enhancers

Abstract

Keywords

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