Polycation cytotoxicity: A delicate matter for nucleic acid therapy -focus on polyethylenimine

Ladan Parhamifar; Anna K. Larsen; A. Christy Hunter; Thomas L. Andresen; S. Moein Moghimi

doi:10.1039/c000190b

Polycation cytotoxicity: A delicate matter for nucleic acid therapy -focus on polyethylenimine

Ladan Parhamifar, Anna K. Larsen, A. Christy Hunter, Thomas L. Andresen, S. Moein Moghimi

Research output: Contribution to journal › Article › peer-review

Abstract

This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery. © 2010 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	4001-4009
Number of pages	8
Journal	Soft Matter
Volume	6
Issue number	17
DOIs	https://doi.org/10.1039/c000190b
Publication status	Published - 7 Sept 2010

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abstract = "This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery. {\textcopyright} 2010 The Royal Society of Chemistry.",

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AU - Moghimi, S. Moein

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AB - This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery. © 2010 The Royal Society of Chemistry.

U2 - 10.1039/c000190b

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JO - Soft Matter

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Polycation cytotoxicity: A delicate matter for nucleic acid therapy -focus on polyethylenimine

Abstract

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