Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity

Vitaliy Khutoryanskiy; Zauresh S. Nurkeeva; Vitaliy V. Khutoryanskiy; Grigoriy A. Mun; Marina V. Sherbakova; Anatoliy T. Ivaschenko; Nazira A. Aitkhozhina

doi:10.1016/S0939-6411(03)00149-8

Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity

Vitaliy Khutoryanskiy, Zauresh S. Nurkeeva, Vitaliy V. Khutoryanskiy, Grigoriy A. Mun, Marina V. Sherbakova, Anatoliy T. Ivaschenko, Nazira A. Aitkhozhina

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Abstract

Complex formation between streptomycin sulfate and poly(acrylic acid) has been studied in aqueous solutions by turbidimetric, potentiometric and viscometric methods as well as by FTIR spectroscopy. It was shown that these polycomplexes are stabilized by electrostatic interactions. The solubility of polycomplexes was examined as a function of pH and it was found that at pH values below 3.1 the polycomplexes undergo complete dissociation or dissolution. The antimicrobial activity of the drug and its polycomplex was evaluated using Sarcina sp. as a model organism. It was demonstrated that the polycomplexes have an antimicrobial activity on the same level as the free drug. © 2003 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	245-249
Number of pages	4
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/S0939-6411(03)00149-8
Publication status	Published - Mar 2004

Keywords

Antibiotic
Drug delivery
Poly(acrylic acid)
Polycomplexes
Streptomycin sulfate

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10.1016/S0939-6411(03)00149-8

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title = "Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity",

abstract = "Complex formation between streptomycin sulfate and poly(acrylic acid) has been studied in aqueous solutions by turbidimetric, potentiometric and viscometric methods as well as by FTIR spectroscopy. It was shown that these polycomplexes are stabilized by electrostatic interactions. The solubility of polycomplexes was examined as a function of pH and it was found that at pH values below 3.1 the polycomplexes undergo complete dissociation or dissolution. The antimicrobial activity of the drug and its polycomplex was evaluated using Sarcina sp. as a model organism. It was demonstrated that the polycomplexes have an antimicrobial activity on the same level as the free drug. {\textcopyright} 2003 Elsevier B.V. All rights reserved.",

keywords = "Antibiotic, Drug delivery, Poly(acrylic acid), Polycomplexes, Streptomycin sulfate",

author = "Vitaliy Khutoryanskiy and Nurkeeva, \{Zauresh S.\} and Khutoryanskiy, \{Vitaliy V.\} and Mun, \{Grigoriy A.\} and Sherbakova, \{Marina V.\} and Ivaschenko, \{Anatoliy T.\} and Aitkhozhina, \{Nazira A.\}",

year = "2004",

month = mar,

doi = "10.1016/S0939-6411(03)00149-8",

language = "English",

volume = "57",

pages = "245--249",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

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publisher = "Elsevier BV",

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TY - JOUR

T1 - Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity

AU - Khutoryanskiy, Vitaliy

AU - Nurkeeva, Zauresh S.

AU - Khutoryanskiy, Vitaliy V.

AU - Mun, Grigoriy A.

AU - Sherbakova, Marina V.

AU - Ivaschenko, Anatoliy T.

AU - Aitkhozhina, Nazira A.

PY - 2004/3

Y1 - 2004/3

N2 - Complex formation between streptomycin sulfate and poly(acrylic acid) has been studied in aqueous solutions by turbidimetric, potentiometric and viscometric methods as well as by FTIR spectroscopy. It was shown that these polycomplexes are stabilized by electrostatic interactions. The solubility of polycomplexes was examined as a function of pH and it was found that at pH values below 3.1 the polycomplexes undergo complete dissociation or dissolution. The antimicrobial activity of the drug and its polycomplex was evaluated using Sarcina sp. as a model organism. It was demonstrated that the polycomplexes have an antimicrobial activity on the same level as the free drug. © 2003 Elsevier B.V. All rights reserved.

AB - Complex formation between streptomycin sulfate and poly(acrylic acid) has been studied in aqueous solutions by turbidimetric, potentiometric and viscometric methods as well as by FTIR spectroscopy. It was shown that these polycomplexes are stabilized by electrostatic interactions. The solubility of polycomplexes was examined as a function of pH and it was found that at pH values below 3.1 the polycomplexes undergo complete dissociation or dissolution. The antimicrobial activity of the drug and its polycomplex was evaluated using Sarcina sp. as a model organism. It was demonstrated that the polycomplexes have an antimicrobial activity on the same level as the free drug. © 2003 Elsevier B.V. All rights reserved.

KW - Antibiotic

KW - Drug delivery

KW - Poly(acrylic acid)

KW - Polycomplexes

KW - Streptomycin sulfate

UR - https://www.scopus.com/pages/publications/1442359735

U2 - 10.1016/S0939-6411(03)00149-8

DO - 10.1016/S0939-6411(03)00149-8

M3 - Article

SN - 0939-6411

VL - 57

SP - 245

EP - 249

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 2

ER -

Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity

Abstract

Keywords

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