Poly(ethylene glycol) block copolymers

N. Tirelli; M. P. Lutolf; A. Napoli; J. A. Hubbell

doi:10.1016/S1389-0352(01)00057-5

Poly(ethylene glycol) block copolymers

N. Tirelli, M. P. Lutolf, A. Napoli, J. A. Hubbell

Research output: Contribution to journal › Article › peer-review

Abstract

The ubiquitous use of poly(ethylene glycol) in the biomaterials field has also boosted the research activity in the chemical derivatization of this polymer. We focused our interest on the preparation of tailor-made poly(ethylene glycol)-based structures and on the study of structure-activity relationships for its functionalization, as preliminary steps for the preparation of smart functional materials. More specifically, amphiphilic and cationic block copolymers were prepared for prospective use in the preparation of self-assembled carriers, and Michael-type addition of thiols onto acrylates was studied as a model for end-group reaction leading to hydrogel formation. © 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	3-15
Number of pages	12
Journal	Reviews in Molecular Biotechnology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/S1389-0352(01)00057-5
Publication status	Published - 2002

Keywords

Amphiphilic polymers
Bioconjugation
Block copolymers
Poly(ethylene glycol)
Polyelectrolytes

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10.1016/S1389-0352(01)00057-5

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title = "Poly(ethylene glycol) block copolymers",

abstract = "The ubiquitous use of poly(ethylene glycol) in the biomaterials field has also boosted the research activity in the chemical derivatization of this polymer. We focused our interest on the preparation of tailor-made poly(ethylene glycol)-based structures and on the study of structure-activity relationships for its functionalization, as preliminary steps for the preparation of smart functional materials. More specifically, amphiphilic and cationic block copolymers were prepared for prospective use in the preparation of self-assembled carriers, and Michael-type addition of thiols onto acrylates was studied as a model for end-group reaction leading to hydrogel formation. {\textcopyright} 2002 Elsevier Science B.V. All rights reserved.",

keywords = "Amphiphilic polymers, Bioconjugation, Block copolymers, Poly(ethylene glycol), Polyelectrolytes",

author = "N. Tirelli and Lutolf, {M. P.} and A. Napoli and Hubbell, {J. A.}",

year = "2002",

doi = "10.1016/S1389-0352(01)00057-5",

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T1 - Poly(ethylene glycol) block copolymers

AU - Tirelli, N.

AU - Lutolf, M. P.

AU - Napoli, A.

AU - Hubbell, J. A.

PY - 2002

Y1 - 2002

N2 - The ubiquitous use of poly(ethylene glycol) in the biomaterials field has also boosted the research activity in the chemical derivatization of this polymer. We focused our interest on the preparation of tailor-made poly(ethylene glycol)-based structures and on the study of structure-activity relationships for its functionalization, as preliminary steps for the preparation of smart functional materials. More specifically, amphiphilic and cationic block copolymers were prepared for prospective use in the preparation of self-assembled carriers, and Michael-type addition of thiols onto acrylates was studied as a model for end-group reaction leading to hydrogel formation. © 2002 Elsevier Science B.V. All rights reserved.

AB - The ubiquitous use of poly(ethylene glycol) in the biomaterials field has also boosted the research activity in the chemical derivatization of this polymer. We focused our interest on the preparation of tailor-made poly(ethylene glycol)-based structures and on the study of structure-activity relationships for its functionalization, as preliminary steps for the preparation of smart functional materials. More specifically, amphiphilic and cationic block copolymers were prepared for prospective use in the preparation of self-assembled carriers, and Michael-type addition of thiols onto acrylates was studied as a model for end-group reaction leading to hydrogel formation. © 2002 Elsevier Science B.V. All rights reserved.

KW - Amphiphilic polymers

KW - Bioconjugation

KW - Block copolymers

KW - Poly(ethylene glycol)

KW - Polyelectrolytes

U2 - 10.1016/S1389-0352(01)00057-5

DO - 10.1016/S1389-0352(01)00057-5

M3 - Article

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VL - 90

SP - 3

EP - 15

JO - Reviews in Molecular Biotechnology

JF - Reviews in Molecular Biotechnology

IS - 1

ER -

Poly(ethylene glycol) block copolymers

Abstract

Keywords

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