Polyethylene oxide-polystyrene oxide triblock copolymers as biological-responsive nanocarriers

Adriana Cambón, Ana Rey-Rico, Silvia Barbosa, Jose Brea, M. I. Loza, Stephen G. Yeates, Carmen Alvarez-Lorenzo, Angel Concheiro, Pablo Taboada, Victor Mosquera

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The present work presents the synthesis, characterization and evaluation of the biocompatibility and ability to dissolve and chemically protect the anticancer drug doxorubicin (DOXO) of two polyethylene oxide-polystyrene oxide triblock copolymers, EO33SO13EO33 and EO 38SO10EO38, where EO and SO denote the ethylene oxide and styrene oxide blocks, respectively. Block copolymer length and SO/EO ratio were selected with the objective of ensuring an optimal compromise between chain solubility, micelle formation ability and core size for enhanced drug solubilization. The temporal stability of the drug-loaded micelles and drug release profile were also analyzed as well as their efficacy as an antitumoral polymeric formulation in vitro by using a multidrug resistant ovarian tumor cell line (NCI-ADR-RES), with the special aim of analyzing the possible capability of both copolymers as potential P-glycoprotein efflux (P-gp) pump inhibitors to enhance DOXO accumulation in this cell line. © 2012 Materials Research Society.
    Original languageEnglish
    Pages (from-to)1-6
    Number of pages5
    JournalMaterials Research Society Symposium Proceedings
    Volume1468
    DOIs
    Publication statusPublished - 2012

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