Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people

Sarah E. Harris; Gail Davies; Michelle Luciano; Antony Payton; Helen C. Fox; Paul Haggarty; William Ollier; Michael Horan; David J. Porteous; John M. Starr; Lawrence J. Whalley; Neil Pendleton; Ian J. Deary

doi:10.3233/JAD-131058

Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people

Sarah E. Harris, Gail Davies, Michelle Luciano, Antony Payton, Helen C. Fox, Paul Haggarty, William Ollier, Michael Horan, David J. Porteous, John M. Starr, Lawrence J. Whalley, Neil Pendleton, Ian J. Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ. © 2014-IOS Press and the authors. All rights reserved.

Original language	English
Pages (from-to)	565-574
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	39
Issue number	3
DOIs	https://doi.org/10.3233/JAD-131058
Publication status	Published - 2014

Keywords

Aging
Alzheimer's disease
cognition
cohort studies
genetics
polygenic traits

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10.3233/JAD-131058

Inequalities in later life frailty and wellbeing: an interdisciplinary approach to causality: Full bid
Nazroo, J. (PI), Burns, A. (CoI), Chandola, T. (CoI), Goodacre, R. (CoI), Horan, M. (CoI), Pendleton, N. (CoI), Tampubolon, G. (CoI) & Wu, F. (CoI)
1/11/11 → 31/12/16
Project: Research

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Harris, S. E., Davies, G., Luciano, M., Payton, A., Fox, H. C., Haggarty, P., Ollier, W., Horan, M., Porteous, D. J., Starr, J. M., Whalley, L. J., Pendleton, N., & Deary, I. J. (2014). Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people. Journal of Alzheimer's Disease, 39(3), 565-574. https://doi.org/10.3233/JAD-131058

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title = "Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people",

abstract = "Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ. {\textcopyright} 2014-IOS Press and the authors. All rights reserved.",

keywords = "Aging, Alzheimer's disease, cognition, cohort studies, genetics, polygenic traits",

author = "Harris, {Sarah E.} and Gail Davies and Michelle Luciano and Antony Payton and Fox, {Helen C.} and Paul Haggarty and William Ollier and Michael Horan and Porteous, {David J.} and Starr, {John M.} and Whalley, {Lawrence J.} and Neil Pendleton and Deary, {Ian J.}",

note = "BB/F022441/1, Biotechnology and Biological Sciences Research Council, United KingdomG0100266, Medical Research Council, United Kingdom, Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom",

year = "2014",

doi = "10.3233/JAD-131058",

language = "English",

volume = "39",

pages = "565--574",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "Sage Publications Ltd",

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Harris, SE, Davies, G, Luciano, M, Payton, A, Fox, HC, Haggarty, P, Ollier, W, Horan, M, Porteous, DJ, Starr, JM, Whalley, LJ, Pendleton, N & Deary, IJ 2014, 'Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people', Journal of Alzheimer's Disease, vol. 39, no. 3, pp. 565-574. https://doi.org/10.3233/JAD-131058

TY - JOUR

T1 - Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people

AU - Harris, Sarah E.

AU - Davies, Gail

AU - Luciano, Michelle

AU - Payton, Antony

AU - Fox, Helen C.

AU - Haggarty, Paul

AU - Ollier, William

AU - Horan, Michael

AU - Porteous, David J.

AU - Starr, John M.

AU - Whalley, Lawrence J.

AU - Pendleton, Neil

AU - Deary, Ian J.

N1 - BB/F022441/1, Biotechnology and Biological Sciences Research Council, United KingdomG0100266, Medical Research Council, United Kingdom, Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom

PY - 2014

Y1 - 2014

N2 - Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ. © 2014-IOS Press and the authors. All rights reserved.

AB - Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ. © 2014-IOS Press and the authors. All rights reserved.

KW - Aging

KW - Alzheimer's disease

KW - cognition

KW - cohort studies

KW - genetics

KW - polygenic traits

U2 - 10.3233/JAD-131058

DO - 10.3233/JAD-131058

M3 - Article

C2 - 24246418

SN - 1387-2877

VL - 39

SP - 565

EP - 574

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 3

ER -

Polygenic risk for alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people

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Keywords

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Inequalities in later life frailty and wellbeing: an interdisciplinary approach to causality: Full bid

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