Polymer-Ceramic Composite Scaffolds: The Effect of Hydroxyapatite and beta-tri-Calcium Phosphate: The Effect of Hydroxyapatite and β-tri-Calcium Phosphate

Boyang Huang; Guilherme Caetano; Cian Vyas; Jonny James Blaker; Carl Diver; Paulo Bártolo

doi:10.3390/ma11010129

Polymer-Ceramic Composite Scaffolds: The Effect of Hydroxyapatite and beta-tri-Calcium Phosphate: The Effect of Hydroxyapatite and β-tri-Calcium Phosphate

Boyang Huang, Guilherme Caetano, Cian Vyas, Jonny James Blaker, Carl Diver, Paulo Bártolo

Research output: Contribution to journal › Article › peer-review

Abstract

The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests. Cell viability, attachment and proliferation tests were performed using human adipose derived stem cells (hADSCs). Results show that scaffolds containing HA present better biological properties and TCP scaffolds present improved mechanical properties. It was also possible to observe that the addition of ceramic particles had no effect on the wettability of the scaffolds.

Original language	English
Article number	129
Journal	Materials
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/ma11010129
Publication status	Published - 14 Jan 2018

Keywords

3D printing
Hydroxyapatite
Scaffold
Tri-calcium phosphate

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title = "Polymer-Ceramic Composite Scaffolds: The Effect of Hydroxyapatite and beta-tri-Calcium Phosphate: The Effect of Hydroxyapatite and β-tri-Calcium Phosphate",

abstract = "The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests. Cell viability, attachment and proliferation tests were performed using human adipose derived stem cells (hADSCs). Results show that scaffolds containing HA present better biological properties and TCP scaffolds present improved mechanical properties. It was also possible to observe that the addition of ceramic particles had no effect on the wettability of the scaffolds.",

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author = "Boyang Huang and Guilherme Caetano and Cian Vyas and Blaker, {Jonny James} and Carl Diver and Paulo B{\'a}rtolo",

note = "Funding Information: Acknowledgments: The authors wish to acknowledge the funding provided by the Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) Centre for Doctoral Training in Regenerative Medicine (EP/L014904/1). This project was partially supported by the EU Marie Curie project “SkelGEN”. Publisher Copyright: {\textcopyright} 2018 by the authors. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Bártolo, Paulo

N1 - Funding Information: Acknowledgments: The authors wish to acknowledge the funding provided by the Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) Centre for Doctoral Training in Regenerative Medicine (EP/L014904/1). This project was partially supported by the EU Marie Curie project “SkelGEN”. Publisher Copyright: © 2018 by the authors. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

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N2 - The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests. Cell viability, attachment and proliferation tests were performed using human adipose derived stem cells (hADSCs). Results show that scaffolds containing HA present better biological properties and TCP scaffolds present improved mechanical properties. It was also possible to observe that the addition of ceramic particles had no effect on the wettability of the scaffolds.

AB - The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests. Cell viability, attachment and proliferation tests were performed using human adipose derived stem cells (hADSCs). Results show that scaffolds containing HA present better biological properties and TCP scaffolds present improved mechanical properties. It was also possible to observe that the addition of ceramic particles had no effect on the wettability of the scaffolds.

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Polymer-Ceramic Composite Scaffolds: The Effect of Hydroxyapatite and beta-tri-Calcium Phosphate: The Effect of Hydroxyapatite and β-tri-Calcium Phosphate

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