Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter, Jacqueline Elsom, Peter P. Wibroe, S. Moein Moghimi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system. © 2012 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)-S20
    JournalNanomedicine: Nanotechnology, Biology, and Medicine
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - Sep 2012

    Keywords

    • Complement
    • Enterocyte
    • Gastrointestinal tract
    • Microparticle
    • Nanoparticle
    • Oral drug delivery
    • Peyers's patch
    • Polymer

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