Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry

R. J. Davey; N. Blagden; G. D. Potts; R. Docherty

doi:10.1021/ja9626345

Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry

R. J. Davey, N. Blagden, G. D. Potts, R. Docherty

Research output: Contribution to journal › Article › peer-review

Abstract

A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.

Original language	English
Pages (from-to)	1767-1772
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	119
Issue number	7
DOIs	https://doi.org/10.1021/ja9626345
Publication status	Published - 19 Feb 1997

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title = "Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry",

abstract = "A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.",

author = "Davey, {R. J.} and N. Blagden and Potts, {G. D.} and R. Docherty",

year = "1997",

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AU - Davey, R. J.

AU - Blagden, N.

AU - Potts, G. D.

AU - Docherty, R.

PY - 1997/2/19

Y1 - 1997/2/19

N2 - A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.

AB - A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.

U2 - 10.1021/ja9626345

DO - 10.1021/ja9626345

M3 - Article

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VL - 119

SP - 1767

EP - 1772

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 7

ER -

Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry

Abstract

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