Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma

Christine F Skibola; Tracy Lightfoot; Luz Agana; Alex Smith; Sara Rollinson; Andrew Kao; Peter Adamson; Gareth J Morgan; Martyn T Smith; Eve Roman

doi:10.1111/j.1365-2141.2005.05505.x

Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma

Christine F Skibola, Tracy Lightfoot, Luz Agana, Alex Smith, Sara Rollinson, Andrew Kao, Peter Adamson, Gareth J Morgan, Martyn T Smith, Eve Roman

University of California

Research output: Contribution to journal › Article › peer-review

Abstract

Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.

Original language	English
Pages (from-to)	618-21
Number of pages	4
Journal	British Journal of Haematology
Volume	129
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2005.05505.x
Publication status	Published - Jun 2005

Keywords

Adolescent
Adult
Case-Control Studies
Confidence Intervals
Female
Genetic Predisposition to Disease
Humans
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic
Risk
Steroid 17-alpha-Hydroxylase
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2141.2005.05505.x

Cite this

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title = "Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma",

abstract = "Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.",

keywords = "Adolescent, Adult, Case-Control Studies, Confidence Intervals, Female, Genetic Predisposition to Disease, Humans, Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Risk, Steroid 17-alpha-Hydroxylase, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",

author = "Skibola, {Christine F} and Tracy Lightfoot and Luz Agana and Alex Smith and Sara Rollinson and Andrew Kao and Peter Adamson and Morgan, {Gareth J} and Smith, {Martyn T} and Eve Roman",

year = "2005",

month = jun,

doi = "10.1111/j.1365-2141.2005.05505.x",

language = "English",

volume = "129",

pages = "618--21",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley & Sons Ltd",

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T1 - Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma

AU - Skibola, Christine F

AU - Lightfoot, Tracy

AU - Agana, Luz

AU - Smith, Alex

AU - Rollinson, Sara

AU - Kao, Andrew

AU - Adamson, Peter

AU - Morgan, Gareth J

AU - Smith, Martyn T

AU - Roman, Eve

PY - 2005/6

Y1 - 2005/6

N2 - Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.

AB - Broad cross-talk exists between the endocrine and immune systems. Estrogen receptor expression in lymphocytes suggests that hormonal modulation may influence lymphoma risk. Analysis of genetic polymorphisms that affect oestrogen production, such as cytochrome P450 17A1 (CYP17A1) -34T>C, may provide insight into oestrogen's role in lymphomagenesis. CYP17A1-34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population-based case-control study. The CYP17A1-34CC genotype was positively associated with NHL [odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis.

KW - Adolescent

KW - Adult

KW - Case-Control Studies

KW - Confidence Intervals

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Lymphoma, B-Cell

KW - Lymphoma, Non-Hodgkin

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Genetic

KW - Risk

KW - Steroid 17-alpha-Hydroxylase

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

U2 - 10.1111/j.1365-2141.2005.05505.x

DO - 10.1111/j.1365-2141.2005.05505.x

M3 - Article

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SN - 0007-1048

VL - 129

SP - 618

EP - 621

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma

Abstract

Keywords

UN SDGs

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