Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus

E. J. Davies, R. P. Donn, M. C. Hillarby, W. E R Ollier

    Research output: Contribution to journalArticlepeer-review


    Objectives - To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). Methods - TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. Results - No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE. Conclusions - These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
    Original languageEnglish
    Pages (from-to)61-63
    Number of pages2
    JournalAnnals of the rheumatic diseases
    Issue number1
    Publication statusPublished - 1994


    Dive into the research topics of 'Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus'. Together they form a unique fingerprint.

    Cite this