Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events

John R. Warmington; Rebecca P. Green; Carol S. Newlon; Stephen G. Oliver

doi:10.1093/nar/15.21.8963

Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events

John R. Warmington, Rebecca P. Green, Carol S. Newlon, Stephen G. Oliver

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Abstract

The region of Saccharomyces cerevisiae chromosome III centromere-distal to the PGK gene is the site of frequent chromosome polymorphisms. We have sequenced this region from fragments of chromosome III isolated from three different yeast strains, GRF88, CN31C and CF4-168. The sequence analysis demonstrates that these polymorphisms are associated with the presence of Ty and delta elements and defines a region of the chromosome which is a hot-spot for transposition events (the RAHS). The three strains can be arranged into a logical evolutionary series in which successive transposition and recombination events insert Ty elements and fuse them with consequent deletions of chromosome and of transposon sequences. The influence of such events on yeast genome evolution is discussed. © 1987 IRL Press Limited.

Original language	English
Pages (from-to)	8963-8982
Number of pages	19
Journal	Nucleic acids research.
Volume	15
Issue number	21
DOIs	https://doi.org/10.1093/nar/15.21.8963
Publication status	Published - 11 Nov 1987

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Manchester Institute of Biotechnology

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title = "Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events",

abstract = "The region of Saccharomyces cerevisiae chromosome III centromere-distal to the PGK gene is the site of frequent chromosome polymorphisms. We have sequenced this region from fragments of chromosome III isolated from three different yeast strains, GRF88, CN31C and CF4-168. The sequence analysis demonstrates that these polymorphisms are associated with the presence of Ty and delta elements and defines a region of the chromosome which is a hot-spot for transposition events (the RAHS). The three strains can be arranged into a logical evolutionary series in which successive transposition and recombination events insert Ty elements and fuse them with consequent deletions of chromosome and of transposon sequences. The influence of such events on yeast genome evolution is discussed. {\textcopyright} 1987 IRL Press Limited.",

author = "Warmington, {John R.} and Green, {Rebecca P.} and Newlon, {Carol S.} and Oliver, {Stephen G.}",

year = "1987",

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doi = "10.1093/nar/15.21.8963",

language = "English",

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journal = "Nucleic acids research.",

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T1 - Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events

AU - Warmington, John R.

AU - Green, Rebecca P.

AU - Newlon, Carol S.

AU - Oliver, Stephen G.

PY - 1987/11/11

Y1 - 1987/11/11

N2 - The region of Saccharomyces cerevisiae chromosome III centromere-distal to the PGK gene is the site of frequent chromosome polymorphisms. We have sequenced this region from fragments of chromosome III isolated from three different yeast strains, GRF88, CN31C and CF4-168. The sequence analysis demonstrates that these polymorphisms are associated with the presence of Ty and delta elements and defines a region of the chromosome which is a hot-spot for transposition events (the RAHS). The three strains can be arranged into a logical evolutionary series in which successive transposition and recombination events insert Ty elements and fuse them with consequent deletions of chromosome and of transposon sequences. The influence of such events on yeast genome evolution is discussed. © 1987 IRL Press Limited.

AB - The region of Saccharomyces cerevisiae chromosome III centromere-distal to the PGK gene is the site of frequent chromosome polymorphisms. We have sequenced this region from fragments of chromosome III isolated from three different yeast strains, GRF88, CN31C and CF4-168. The sequence analysis demonstrates that these polymorphisms are associated with the presence of Ty and delta elements and defines a region of the chromosome which is a hot-spot for transposition events (the RAHS). The three strains can be arranged into a logical evolutionary series in which successive transposition and recombination events insert Ty elements and fuse them with consequent deletions of chromosome and of transposon sequences. The influence of such events on yeast genome evolution is discussed. © 1987 IRL Press Limited.

U2 - 10.1093/nar/15.21.8963

DO - 10.1093/nar/15.21.8963

M3 - Article

C2 - 2825123

SN - 1362-4962

VL - 15

SP - 8963

EP - 8982

JO - Nucleic acids research.

JF - Nucleic acids research.

IS - 21

ER -

Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events

Abstract

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