Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping

H Chinoy; Fiona Salway; W Thomson; AJ Silman; WER Ollier; RG Cooper

Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping

H Chinoy, Fiona Salway, W Thomson, AJ Silman, WER Ollier, RG Cooper

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to conference › Other

Abstract

Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 150 cases.AIMS: To determine whether HLA-DRB1 genotype can discriminate between PM and DM in a UK white caucasoid population.METHODS: 150 adult UK white patients; PM, n=74 (25 males, 56.8 ± 13.9 years), DM, n=76 (25 males, 50.7 ± 12.3 years) with definite disease, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with an ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

Original language	English
Pages	S397-S397
Publication status	Published - Sept 2002
Event	66th Annual Scientific Meeting of the American-College-of-Rheumatology - New Orleans, Louisiana Duration: 24 Sept 2002 → 29 Sept 2002

Conference

Conference	66th Annual Scientific Meeting of the American-College-of-Rheumatology
City	New Orleans, Louisiana
Period	24/09/02 → 29/09/02

Keywords

Dermatomyositis
Polymyositis
HLA

Cite this

@conference{7d324018262b4919a71246dda5af1029,

title = "Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping",

abstract = "Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 150 cases.AIMS: To determine whether HLA-DRB1 genotype can discriminate between PM and DM in a UK white caucasoid population.METHODS: 150 adult UK white patients; PM, n=74 (25 males, 56.8 ± 13.9 years), DM, n=76 (25 males, 50.7 ± 12.3 years) with definite disease, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with an ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p",

keywords = "Dermatomyositis, Polymyositis, HLA",

author = "H Chinoy and Fiona Salway and W Thomson and AJ Silman and WER Ollier and RG Cooper",

note = "IDS Number: 600ZN ISSN: 0004-3591; 66th Annual Scientific Meeting of the American-College-of-Rheumatology ; Conference date: 24-09-2002 Through 29-09-2002",

year = "2002",

month = sep,

language = "English",

pages = "S397--S397",

}

TY - CONF

T1 - Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping

AU - Chinoy, H

AU - Salway, Fiona

AU - Thomson, W

AU - Silman, AJ

AU - Ollier, WER

AU - Cooper, RG

N1 - IDS Number: 600ZN ISSN: 0004-3591

PY - 2002/9

Y1 - 2002/9

N2 - Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 150 cases.AIMS: To determine whether HLA-DRB1 genotype can discriminate between PM and DM in a UK white caucasoid population.METHODS: 150 adult UK white patients; PM, n=74 (25 males, 56.8 ± 13.9 years), DM, n=76 (25 males, 50.7 ± 12.3 years) with definite disease, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with an ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

AB - Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 150 cases.AIMS: To determine whether HLA-DRB1 genotype can discriminate between PM and DM in a UK white caucasoid population.METHODS: 150 adult UK white patients; PM, n=74 (25 males, 56.8 ± 13.9 years), DM, n=76 (25 males, 50.7 ± 12.3 years) with definite disease, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with an ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

KW - Dermatomyositis

KW - Polymyositis

KW - HLA

M3 - Other

SP - S397-S397

T2 - 66th Annual Scientific Meeting of the American-College-of-Rheumatology

Y2 - 24 September 2002 through 29 September 2002

ER -

Polymyositis (PM) and dermatomyositis (DM) can be genetically discriminated by HLA-DRB1 genotyping

Abstract

Conference

Keywords

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Cite this