Population genetics of rheumatoid arthritis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hypervariable region of the molecule. This 'shared epitope' is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this 'shared epitope' in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.
    Original languageEnglish
    Pages (from-to)741-759
    Number of pages18
    JournalRheumatic Disease Clinics of North America
    Volume18
    Issue number4
    Publication statusPublished - 1992

    Keywords

    • REVIEW ARTICLES
    • REVIEWS,EDITORIALS & CHAPTERS

    Fingerprint

    Dive into the research topics of 'Population genetics of rheumatoid arthritis'. Together they form a unique fingerprint.

    Cite this