Population genetics of rheumatoid arthritis

W. Ollier; W. Thomson

Population genetics of rheumatoid arthritis

Research output: Contribution to journal › Article › peer-review

Abstract

A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hypervariable region of the molecule. This 'shared epitope' is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this 'shared epitope' in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.

Original language	English
Pages (from-to)	741-759
Number of pages	18
Journal	Rheumatic Disease Clinics of North America
Volume	18
Issue number	4
Publication status	Published - 1992

Keywords

REVIEW ARTICLES
REVIEWS,EDITORIALS & CHAPTERS

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title = "Population genetics of rheumatoid arthritis",

abstract = "A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hypervariable region of the molecule. This 'shared epitope' is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this 'shared epitope' in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.",

keywords = "REVIEW ARTICLES, REVIEWS,EDITORIALS & CHAPTERS",

author = "W. Ollier and W. Thomson",

note = "UI - 93087816 LA - eng RN - 0 (Epitopes) RN - 0 (HLA-DR Antigens) RN - 0 (Histocompatibility Antigens Class II) RN - 128338-86-3 (HLA-DRB1) RN - 9007-49-2 (DNA) PT - Journal Article PT - Review PT - Review, Tutorial DA - 19930104 IS - 0889-857X SB - IM CY - UNITED STATES",

year = "1992",

language = "English",

volume = "18",

pages = "741--759",

journal = "Rheumatic Disease Clinics of North America",

issn = "1558-3163",

publisher = "W.B. Saunders Co. Ltd",

number = "4",

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TY - JOUR

T1 - Population genetics of rheumatoid arthritis

AU - Ollier, W.

AU - Thomson, W.

N1 - UI - 93087816 LA - eng RN - 0 (Epitopes) RN - 0 (HLA-DR Antigens) RN - 0 (Histocompatibility Antigens Class II) RN - 128338-86-3 (HLA-DRB1) RN - 9007-49-2 (DNA) PT - Journal Article PT - Review PT - Review, Tutorial DA - 19930104 IS - 0889-857X SB - IM CY - UNITED STATES

PY - 1992

Y1 - 1992

N2 - A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hypervariable region of the molecule. This 'shared epitope' is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this 'shared epitope' in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.

AB - A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hypervariable region of the molecule. This 'shared epitope' is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this 'shared epitope' in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.

KW - REVIEW ARTICLES

KW - REVIEWS,EDITORIALS & CHAPTERS

M3 - Article

SN - 1558-3163

VL - 18

SP - 741

EP - 759

JO - Rheumatic Disease Clinics of North America

JF - Rheumatic Disease Clinics of North America

IS - 4

ER -

Population genetics of rheumatoid arthritis

Abstract

Keywords

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