Porous methacrylate tissue engineering scaffolds: using carbon dioxide to control porosity and interconnectivity

John J A Barry, Marta M C G Silva, Sarah H Cartmell, Robert E Guldberg, Colin A Scotchford, Steven M Howdle

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Porous scaffold structures are used in tissue engineering to provide structural guidance for regenerating tissues. The use of carbon dioxide (CO2) to create such scaffolds has received some attention in the past but many researchers believe that although CO2 processing of polymers can lead to porous scaffolds there is limited interconnectivity between the pores. In this study, highly porous (greater than 85%) and well interconnected scaffolds were obtained in which the size, distribution and no. of pores could be controlled. This control was achieved by altering the rate of venting from polymer disks satd. with CO2 under modest temp. and pressure. The polymer used is a blend of poly (Et methacrylate) and tetrahydrofurfuryl methacrylate (PEMA/THFMA). This polymer system has shown promise for potential applications in cartilage repair. [on SciFinder(R)]
    Original languageEnglish
    Pages (from-to)4197-4204
    Number of pages8
    JournalJournal of Materials Science
    Volume41
    Issue number13
    Publication statusPublished - 2006

    Keywords

    • Bone (artificial
    • porous methacrylate tissue engineering scaffolds prepd. by using carbon dioxide to control porosity and interconnectivity)
    • Compressive strength
    • Particle size distribution
    • Pore size
    • Porosity
    • Prosthetic materials and Prosthetics
    • Regeneration (porous methacrylate tissue engineering scaffolds prepd. by using carbon dioxide to control porosity and interconnectivity)
    • Polymer blends Role: PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (porous methacrylate tissue engineering scaffolds prepd. by using carbon dioxide to control porosity and interconnectivity)
    • carbon dioxide methacrylate porosity tissue engineering

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