Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Pankaz K. Sharma; Rouslan Kevorkiants; Sam P. De Visser; Devesh Kumar; Sason Shaik

doi:10.1002/anie.200352943

Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Pankaz K. Sharma, Rouslan Kevorkiants, Sam P. De Visser, Devesh Kumar, Sason Shaik

Research output: Contribution to journal › Article › peer-review

Abstract

Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme-oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.

Original language	English
Pages (from-to)	1129-1132
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	9
DOIs	https://doi.org/10.1002/anie.200352943
Publication status	Published - 20 Feb 2004

Keywords

Density functional calculations
Enzyme catalysis
Enzyme models
Heme proteins
Oxygenation

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10.1002/anie.200352943

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abstract = "Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme-oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.",

keywords = "Density functional calculations, Enzyme catalysis, Enzyme models, Heme proteins, Oxygenation",

author = "Sharma, {Pankaz K.} and Rouslan Kevorkiants and {De Visser}, {Sam P.} and Devesh Kumar and Sason Shaik",

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AU - Sharma, Pankaz K.

AU - Kevorkiants, Rouslan

AU - De Visser, Sam P.

AU - Kumar, Devesh

AU - Shaik, Sason

PY - 2004/2/20

Y1 - 2004/2/20

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AB - Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme-oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.

KW - Density functional calculations

KW - Enzyme catalysis

KW - Enzyme models

KW - Heme proteins

KW - Oxygenation

U2 - 10.1002/anie.200352943

DO - 10.1002/anie.200352943

M3 - Article

SN - 1433-7851

VL - 43

SP - 1129

EP - 1132

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 9

ER -

Porphyrin traps its terminator! Concerted and stepwise porphyrin degradation mechanisms induced by heme-oxygenase and cytochrome P450

Abstract

Keywords

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