Positive association of HLA-DRB1*15 with Dupuytren's disease in Caucasians

J. J. Brown, W. Ollier, W. Thomson, A. Bayat

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Dupuytren's disease (DD) is a permanent nodular condition affecting the palms and digits of the hands, leading to progressive shortening and contractures of the digits often resulting in diminished function and severe deformity. DD is thought to be one of the most common hereditary connective tissue disorders in Caucasians. To elucidate further the aetiology of DD, we compared the HLA-DRB1 phenotype frequencies of DD patients (n = 67) against the HLA-DRB1 phenotype frequencies observed in a control population (n = 537). HLA-DRB1*15 phenotype frequency was higher in DD positive Caucasoids (37.3%) when compared with control data (20.9%) (corrected P = 0.029): we conclude that in Caucasoids of European origin, HLA-DRB1*15 is associated with risk of developing DD. © 2008 The Authors.
    Original languageEnglish
    Pages (from-to)166-170
    Number of pages4
    JournalTissue Antigens
    Volume72
    Issue number2
    DOIs
    Publication statusPublished - Aug 2008

    Keywords

    • Caucasian ethnicity
    • Dupuytren contracture
    • Dupuytren's disease
    • HLA-DRB1
    • Major histocompatibility complex
    • Polymerase chain reaction-sequence-specific oligonucleotide probe

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