Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

Rebecca Lamb; Wendy Thomson; Emma M Ogilvie; Rachelle Donn; M. Abinun; M. Becker; A. Bell; A. Craft; E. Crawley; J. David; H. Foster; J. Gardener-Medwin; J. Griffin; A. Hall; M. Hall; A. Herrick; P. Hollingworth; L. Holt; S. Jones; G. Pountain; C. Ryder; T. Southwood; I. Stewart; H. Venning; L. Wedderburn; P. Woo; S. Wyatt

doi:10.1002/art.22444

Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

Rebecca Lamb, Wendy Thomson, Emma M Ogilvie, Rachelle Donn, M. Abinun, M. Becker, A. Bell, A. Craft, E. Crawley, J. David, H. Foster, J. Gardener-Medwin, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. Holt, S. Jones, G. PountainC. Ryder, T. Southwood, I. Stewart, H. Venning, L. Wedderburn, P. Woo, S. Wyatt

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA). METHODS: Nine polymorphisms across the SLC26A2 gene locus were investigated using MassArray genotyping in 826 UK Caucasian JIA cases and 617 ethnically matched healthy controls. RESULTS: Significant associations between multiple single-nucleotide polymorphisms (SNPs) across SLC26A2 and systemic-onset JIA were found. In each case, homozygosity for the minor allele conferred the increased risk of disease susceptibility: rs1541915 (odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.7, P=0.0003), rs245056 (OR 2.8, 95% CI 1.7-4.6, P=0.00002), rs245055 (OR 2.5, 95% CI 1.2-5.0, P=0.004), rs245051 (OR 2.3, 95% CI 1.4-3.7, P=0.0005), rs245076 (OR 2.7, 95% CI 1.3-5.4, P=0.0015), and rs8073 (OR 2.3, 95% CI 0.9-5.6, P=0.04). CONCLUSION: These findings show the value of using monogenic disease loci as candidates for investigation in JIA. We identified a subgroup-specific association between SNPs within the SLC26A2 gene and systemic-onset JIA. Our findings also highlight systemic-onset JIA as being a distinctly different disease from that in the other JIA subgroups.

Original language	English
Pages (from-to)	1286-1291
Number of pages	5
Journal	Arthritis Care & Research
Volume	56
Issue number	4
DOIs	https://doi.org/10.1002/art.22444
Publication status	Published - Apr 2007

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Lamb, R., Thomson, W., Ogilvie, E. M., Donn, R., Abinun, M., Becker, M., Bell, A., Craft, A., Crawley, E., David, J., Foster, H., Gardener-Medwin, J., Griffin, J., Hall, A., Hall, M., Herrick, A., Hollingworth, P., Holt, L., Jones, S., ... Wyatt, S. (2007). Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis Care & Research, 56(4), 1286-1291. https://doi.org/10.1002/art.22444

@article{05db0a08312d4222b5548ab9386ca0ee,

title = "Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.",

abstract = "OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA). METHODS: Nine polymorphisms across the SLC26A2 gene locus were investigated using MassArray genotyping in 826 UK Caucasian JIA cases and 617 ethnically matched healthy controls. RESULTS: Significant associations between multiple single-nucleotide polymorphisms (SNPs) across SLC26A2 and systemic-onset JIA were found. In each case, homozygosity for the minor allele conferred the increased risk of disease susceptibility: rs1541915 (odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.7, P=0.0003), rs245056 (OR 2.8, 95% CI 1.7-4.6, P=0.00002), rs245055 (OR 2.5, 95% CI 1.2-5.0, P=0.004), rs245051 (OR 2.3, 95% CI 1.4-3.7, P=0.0005), rs245076 (OR 2.7, 95% CI 1.3-5.4, P=0.0015), and rs8073 (OR 2.3, 95% CI 0.9-5.6, P=0.04). CONCLUSION: These findings show the value of using monogenic disease loci as candidates for investigation in JIA. We identified a subgroup-specific association between SNPs within the SLC26A2 gene and systemic-onset JIA. Our findings also highlight systemic-onset JIA as being a distinctly different disease from that in the other JIA subgroups.",

author = "Rebecca Lamb and Wendy Thomson and Ogilvie, {Emma M} and Rachelle Donn and M. Abinun and M. Becker and A. Bell and A. Craft and E. Crawley and J. David and H. Foster and J. Gardener-Medwin and J. Griffin and A. Hall and M. Hall and A. Herrick and P. Hollingworth and L. Holt and S. Jones and G. Pountain and C. Ryder and T. Southwood and I. Stewart and H. Venning and L. Wedderburn and P. Woo and S. Wyatt",

year = "2007",

month = apr,

doi = "10.1002/art.22444",

language = "English",

volume = "56",

pages = "1286--1291",

journal = "Arthritis Care & Research",

issn = "2151-4658",

publisher = "John Wiley & Sons Ltd",

number = "4",

}

Lamb, R, Thomson, W, Ogilvie, EM, Donn, R, Abinun, M, Becker, M, Bell, A, Craft, A, Crawley, E, David, J, Foster, H, Gardener-Medwin, J, Griffin, J, Hall, A, Hall, M, Herrick, A, Hollingworth, P, Holt, L, Jones, S, Pountain, G, Ryder, C, Southwood, T, Stewart, I, Venning, H, Wedderburn, L, Woo, P & Wyatt, S 2007, 'Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.', Arthritis Care & Research, vol. 56, no. 4, pp. 1286-1291. https://doi.org/10.1002/art.22444

TY - JOUR

T1 - Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

AU - Lamb, Rebecca

AU - Thomson, Wendy

AU - Ogilvie, Emma M

AU - Donn, Rachelle

AU - Abinun, M.

AU - Becker, M.

AU - Bell, A.

AU - Craft, A.

AU - Crawley, E.

AU - David, J.

AU - Foster, H.

AU - Gardener-Medwin, J.

AU - Griffin, J.

AU - Hall, A.

AU - Hall, M.

AU - Herrick, A.

AU - Hollingworth, P.

AU - Holt, L.

AU - Jones, S.

AU - Pountain, G.

AU - Ryder, C.

AU - Southwood, T.

AU - Stewart, I.

AU - Venning, H.

AU - Wedderburn, L.

AU - Woo, P.

AU - Wyatt, S.

PY - 2007/4

Y1 - 2007/4

N2 - OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA). METHODS: Nine polymorphisms across the SLC26A2 gene locus were investigated using MassArray genotyping in 826 UK Caucasian JIA cases and 617 ethnically matched healthy controls. RESULTS: Significant associations between multiple single-nucleotide polymorphisms (SNPs) across SLC26A2 and systemic-onset JIA were found. In each case, homozygosity for the minor allele conferred the increased risk of disease susceptibility: rs1541915 (odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.7, P=0.0003), rs245056 (OR 2.8, 95% CI 1.7-4.6, P=0.00002), rs245055 (OR 2.5, 95% CI 1.2-5.0, P=0.004), rs245051 (OR 2.3, 95% CI 1.4-3.7, P=0.0005), rs245076 (OR 2.7, 95% CI 1.3-5.4, P=0.0015), and rs8073 (OR 2.3, 95% CI 0.9-5.6, P=0.04). CONCLUSION: These findings show the value of using monogenic disease loci as candidates for investigation in JIA. We identified a subgroup-specific association between SNPs within the SLC26A2 gene and systemic-onset JIA. Our findings also highlight systemic-onset JIA as being a distinctly different disease from that in the other JIA subgroups.

AB - OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA). METHODS: Nine polymorphisms across the SLC26A2 gene locus were investigated using MassArray genotyping in 826 UK Caucasian JIA cases and 617 ethnically matched healthy controls. RESULTS: Significant associations between multiple single-nucleotide polymorphisms (SNPs) across SLC26A2 and systemic-onset JIA were found. In each case, homozygosity for the minor allele conferred the increased risk of disease susceptibility: rs1541915 (odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.7, P=0.0003), rs245056 (OR 2.8, 95% CI 1.7-4.6, P=0.00002), rs245055 (OR 2.5, 95% CI 1.2-5.0, P=0.004), rs245051 (OR 2.3, 95% CI 1.4-3.7, P=0.0005), rs245076 (OR 2.7, 95% CI 1.3-5.4, P=0.0015), and rs8073 (OR 2.3, 95% CI 0.9-5.6, P=0.04). CONCLUSION: These findings show the value of using monogenic disease loci as candidates for investigation in JIA. We identified a subgroup-specific association between SNPs within the SLC26A2 gene and systemic-onset JIA. Our findings also highlight systemic-onset JIA as being a distinctly different disease from that in the other JIA subgroups.

U2 - 10.1002/art.22444

DO - 10.1002/art.22444

M3 - Article

C2 - 17393463

SN - 2151-4658

VL - 56

SP - 1286

EP - 1291

JO - Arthritis Care & Research

JF - Arthritis Care & Research

IS - 4

ER -

Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

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