Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

L B Been; P H Elsinga; J de Vries; D C P Cobben; P L Jager; H J Hoekstra; A J H Suurmeijer

doi:10.1016/j.ejso.2005.09.011

Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

L B Been
, P H Elsinga
, J de Vries
, D C P Cobben
, P L Jager
, H J Hoekstra
, A J H Suurmeijer

Division of Cancer Sciences (L5)

Rijksuniversiteit Groningen (University of Groningen)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.

METHODS: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla.

RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.

CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.ejso.2005.09.011
Publication status	Published - Feb 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Axilla
Breast Neoplasms
Carcinoma
Dideoxynucleosides
Feasibility Studies
Female
Fluorine Radioisotopes
Humans
Lymph Nodes
Lymphatic Metastasis
Mastectomy
Middle Aged
Pilot Projects
Positron-Emission Tomography
Preoperative Care
Prospective Studies
Reproducibility of Results
Sentinel Lymph Node Biopsy
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

Access to Document

10.1016/j.ejso.2005.09.011

Cite this

Been, L. B., Elsinga, P. H., de Vries, J., Cobben, D. C. P., Jager, P. L., Hoekstra, H. J., & Suurmeijer, A. J. H. (2006). Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 32(1), 39-43. https://doi.org/10.1016/j.ejso.2005.09.011

@article{01afdb8f0f804f70835ad6b408dfc39a,

title = "Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study",

abstract = "BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.METHODS: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla.RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.",

keywords = "Adult, Aged, Axilla, Breast Neoplasms, Carcinoma, Dideoxynucleosides, Feasibility Studies, Female, Fluorine Radioisotopes, Humans, Lymph Nodes, Lymphatic Metastasis, Mastectomy, Middle Aged, Pilot Projects, Positron-Emission Tomography, Preoperative Care, Prospective Studies, Reproducibility of Results, Sentinel Lymph Node Biopsy, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "Been, \{L B\} and Elsinga, \{P H\} and \{de Vries\}, J and Cobben, \{D C P\} and Jager, \{P L\} and Hoekstra, \{H J\} and Suurmeijer, \{A J H\}",

year = "2006",

month = feb,

doi = "10.1016/j.ejso.2005.09.011",

language = "English",

volume = "32",

pages = "39--43",

journal = "European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",

issn = "0748-7983",

publisher = "W.B. Saunders Co. Ltd",

number = "1",

}

Been, LB, Elsinga, PH, de Vries, J, Cobben, DCP, Jager, PL, Hoekstra, HJ & Suurmeijer, AJH 2006, 'Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study', European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 32, no. 1, pp. 39-43. https://doi.org/10.1016/j.ejso.2005.09.011

Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study. / Been, L B; Elsinga, P H; de Vries, J et al.
In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol. 32, No. 1, 02.2006, p. 39-43.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

AU - Been, L B

AU - Elsinga, P H

AU - de Vries, J

AU - Cobben, D C P

AU - Jager, P L

AU - Hoekstra, H J

AU - Suurmeijer, A J H

PY - 2006/2

Y1 - 2006/2

N2 - BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.METHODS: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla.RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.

AB - BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer.METHODS: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla.RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases.CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.

KW - Adult

KW - Aged

KW - Axilla

KW - Breast Neoplasms

KW - Carcinoma

KW - Dideoxynucleosides

KW - Feasibility Studies

KW - Female

KW - Fluorine Radioisotopes

KW - Humans

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Mastectomy

KW - Middle Aged

KW - Pilot Projects

KW - Positron-Emission Tomography

KW - Preoperative Care

KW - Prospective Studies

KW - Reproducibility of Results

KW - Sentinel Lymph Node Biopsy

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ejso.2005.09.011

DO - 10.1016/j.ejso.2005.09.011

M3 - Article

C2 - 16269226

SN - 0748-7983

VL - 32

SP - 39

EP - 43

JO - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

IS - 1

ER -

Been LB, Elsinga PH, de Vries J, Cobben DCP, Jager PL, Hoekstra HJ et al. Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2006 Feb;32(1):39-43. doi: 10.1016/j.ejso.2005.09.011

Positron emission tomography in patients with breast cancer using (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT)-a pilot study

Abstract

UN SDGs

Keywords

Research Beacons, Institutes and Platforms

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