Potential biomarkers of osteonecrosis in Gaucher disease

Elena V. Pavlova, Patrick B. Deegan, Jane Tindall, Ian McFarlane, Atul Mehta, Derralyn Hughes, J. Edmond Wraith, Timothy M. Cox

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: To investigate the relationship between chemokines and cytokines and osteonecrosis in Gaucher disease, we conducted multiplex assays in a cohort of 100 adult patients. Methods: Mean age was 45. years (18-86); 92 Gaucher patients received imiglucerase (median duration 8. years (2-18)). Forty-three had experienced osteonecrosis (ON), and eight had ON despite enzyme therapy. Serum cytokines/chemokines were determined by fluorimetric bead arrays in samples from Gaucher patients and healthy volunteers (10 males and 10 females). Intra-assay and inter-assay coefficients of variation were 2%-9.8% and 5.6%-15%, respectively. Results: VEGF and CCL5/RANTES did not differ between Gaucher and control samples. Concentrations of CCL3/MIP-1α, CCL4/MIP-1β, CCL2/MCP-1, CXCL8/IL-8, IL-1ra and CCL18/PARC were elevated in Gaucher patients (p
    Original languageEnglish
    Pages (from-to)27-33
    Number of pages6
    JournalBlood Cells, Molecules, and Diseases
    Volume46
    Issue number1
    DOIs
    Publication statusPublished - 15 Jan 2011

    Keywords

    • Biomarkers
    • Enzyme replacement therapy
    • Gaucher disease
    • Multiplex flow cytometric bead array assay
    • Osteonecrosis (avascular necrosis)

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