Practical aspects of real-time pure shift HSQC experiments

    Research output: Contribution to journalArticlepeer-review


    Pure shift NMR spectroscopy has become an efficient tool for improving
    resolution in proton NMR spectra by removing the effect of homonuclear couplings. The introduction of real-time acquisition methods has allowed the main drawback of pure shift NMR, the long experiment times needed, to be circumvented. Real-time methods use periodic application of J-refocusing pulse sequence elements, acquiring a single free induction decay, in contrast to previous methods that construct a pure shift interferogram by concatenating excerpts from multiple free induction decays. In the important HSQC experiment, implementing real-time pure shift data acquisition typically leads to the simultaneous improvement of both resolution and sensitivity. The current limitations of and problems with real-time pure shift acquisition methods are
    discussed here in the context of HSQC experiments. We aim to provide a detailed
    account of the technical challenges, together with a practical guide to exploiting the full potential of such methods.
    Original languageEnglish
    JournalMagnetic Resonance in Chemistry
    Publication statusPublished - 23 Dec 2017


    • pure shift
    • HSQC
    • NMR
    • Real-time
    • homodecoupling


    Dive into the research topics of 'Practical aspects of real-time pure shift HSQC experiments'. Together they form a unique fingerprint.

    Cite this