TY - JOUR
T1 - Pragmatic target discovery from novel gene to functionally defined drug target: the interleukin-1 story.
AU - Allan, Stuart McRae
PY - 2005
Y1 - 2005
N2 - The pro-inflammatory cytokine interleukin-1 (IL-1) has been proposed as a mediator of the acute neurodegenerative changes that occur following stroke. This is based largely on experimental studies in rodents, in particular the marked reduction in ischemic cell death seen when IL-1 receptor antagonist (IL-1ra) is administered. Mechanisms of IL-1 action remain largely unknown, but they may involve complex effects on many cells including microglia, astrocytes, neurons, and endothelial cells. In light of this, IL-1ra is currently under consideration as a potential treatment for stroke and other neurodegenerative conditions.
AB - The pro-inflammatory cytokine interleukin-1 (IL-1) has been proposed as a mediator of the acute neurodegenerative changes that occur following stroke. This is based largely on experimental studies in rodents, in particular the marked reduction in ischemic cell death seen when IL-1 receptor antagonist (IL-1ra) is administered. Mechanisms of IL-1 action remain largely unknown, but they may involve complex effects on many cells including microglia, astrocytes, neurons, and endothelial cells. In light of this, IL-1ra is currently under consideration as a potential treatment for stroke and other neurodegenerative conditions.
U2 - 10.1385/1-59259-836-6:333
DO - 10.1385/1-59259-836-6:333
M3 - Article
C2 - 15454676
SN - 1940-6037
VL - 104
SP - 333
EP - 346
JO - Methods in Molecular Medicine
JF - Methods in Molecular Medicine
ER -
