Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: a double-blind randomised placebo-controlled clinical trial

Sara Ud-Din; Traci A Wilgus; Douglas D McGeorge; Ardeshir Bayat

doi:10.3390/pharmaceutics13040510

Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: a double-blind randomised placebo-controlled clinical trial

Sara Ud-Din, Traci A Wilgus, Douglas D McGeorge, Ardeshir Bayat

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The concept of pre-emptive priming of skin pre-surgery offers a novel approach in optimizing cutaneous scarring outcome. We previously showed an anti-scarring topical (epigallocatechin-3-gallate (EGCG)) is effective in improving skin scarring when applied post-surgery. The objective was to deliver an active compound at the optimal time in order to maximise its impact and improve cutaneous scarring. Therefore, pre-emptive application of anti-scarring topical pre-surgery compared with post-surgery may potentially be superior on scarring outcome.

Original language	English
Journal	Pharmaceutics
Early online date	8 Apr 2021
DOIs	https://doi.org/10.3390/pharmaceutics13040510
Publication status	E-pub ahead of print - 8 Apr 2021

Access to Document

10.3390/pharmaceutics13040510Licence: CC BY

Fingerprint

Dive into the research topics of 'Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: a double-blind randomised placebo-controlled clinical trial'. Together they form a unique fingerprint.

Cite this

@article{e0c214a74c1d4399bbfe436d9d8691ea,

title = "Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: a double-blind randomised placebo-controlled clinical trial",

abstract = "Background: The concept of pre-emptive priming of skin pre-surgery offers a novel approach in optimizing cutaneous scarring outcome. We previously showed an anti-scarring topical (epigallocatechin-3-gallate (EGCG)) is effective in improving skin scarring when applied post-surgery. The objective was to deliver an active compound at the optimal time in order to maximise its impact and improve cutaneous scarring. Therefore, pre-emptive application of anti-scarring topical pre-surgery compared with post-surgery may potentially be superior on scarring outcome.",

author = "Sara Ud-Din and Wilgus, {Traci A} and McGeorge, {Douglas D} and Ardeshir Bayat",

year = "2021",

month = apr,

day = "8",

doi = "10.3390/pharmaceutics13040510",

language = "English",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI",

}

TY - JOUR

T1 - Pre-emptive priming of human skin improves cutaneous scarring and is superior to immediate and delayed topical anti-scarring treatment post-wounding: a double-blind randomised placebo-controlled clinical trial

AU - Ud-Din, Sara

AU - Wilgus, Traci A

AU - McGeorge, Douglas D

AU - Bayat, Ardeshir

PY - 2021/4/8

Y1 - 2021/4/8

N2 - Background: The concept of pre-emptive priming of skin pre-surgery offers a novel approach in optimizing cutaneous scarring outcome. We previously showed an anti-scarring topical (epigallocatechin-3-gallate (EGCG)) is effective in improving skin scarring when applied post-surgery. The objective was to deliver an active compound at the optimal time in order to maximise its impact and improve cutaneous scarring. Therefore, pre-emptive application of anti-scarring topical pre-surgery compared with post-surgery may potentially be superior on scarring outcome.

AB - Background: The concept of pre-emptive priming of skin pre-surgery offers a novel approach in optimizing cutaneous scarring outcome. We previously showed an anti-scarring topical (epigallocatechin-3-gallate (EGCG)) is effective in improving skin scarring when applied post-surgery. The objective was to deliver an active compound at the optimal time in order to maximise its impact and improve cutaneous scarring. Therefore, pre-emptive application of anti-scarring topical pre-surgery compared with post-surgery may potentially be superior on scarring outcome.

U2 - 10.3390/pharmaceutics13040510

DO - 10.3390/pharmaceutics13040510

M3 - Article

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

ER -