Precision mapping of the metabolome

Rainer Breitling; Andrew R. Pitt; Michael P. Barrett

doi:10.1016/j.tibtech.2006.10.006

Precision mapping of the metabolome

Rainer Breitling, Andrew R. Pitt, Michael P. Barrett

Research output: Contribution to journal › Article › peer-review

Abstract

The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	543-548
Number of pages	5
Journal	Trends in Biotechnology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1016/j.tibtech.2006.10.006
Publication status	Published - Dec 2006

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10.1016/j.tibtech.2006.10.006

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title = "Precision mapping of the metabolome",

abstract = "The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

author = "Rainer Breitling and Pitt, {Andrew R.} and Barrett, {Michael P.}",

year = "2006",

month = dec,

doi = "10.1016/j.tibtech.2006.10.006",

language = "English",

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journal = "Trends in Biotechnology",

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AU - Breitling, Rainer

AU - Pitt, Andrew R.

AU - Barrett, Michael P.

PY - 2006/12

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N2 - The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism. © 2006 Elsevier Ltd. All rights reserved.

AB - The global study of the structure and dynamics of metabolic networks has been hindered by a lack of techniques that identify metabolites and their biochemical relationship in complex mixtures. The recent application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) to metabolomic analysis suggests a way to tackle the problem. A lower-cost alternative to high-field FTICR-MS, the Orbitrap mass analyzer, promises accelerated activity in this area. Here, we show how the ultra-high mass accuracy and resolution provided by this new generation of mass spectrometers can help to identify metabolites and connect them into metabolic networks. Data from perturbation studies and isotope-tracking experiments can complement this information to create metabolic maps de novo and chart unexplored areas of metabolism. © 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tibtech.2006.10.006

DO - 10.1016/j.tibtech.2006.10.006

M3 - Article

SN - 0167-7799

VL - 24

SP - 543

EP - 548

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 12

ER -

Precision mapping of the metabolome

Abstract

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