Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers

M Mian, Mairead Mcnamara, M Doherty, D Hedley, JJ Knox, S Serra

    Research output: Contribution to journalArticlepeer-review


    AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC). METHODS: Expressions of ERCC1 and XRCC1 were determined by immunohistochemistry (IHC) for 160 patients with BTC and association with clinicopathological features and patient survival was performed to evaluate their predictive and prognostic values. RESULTS: Neoplastic tissue showed much lower nuclear expression compared with non-neoplastic tissue for ERCC1 (median immunostaining score (IS)=0.7 (95% CI 0.2 to 1.3) vs 8.0 (95% CI 5.5 to 8.0), p
    Original languageEnglish
    JournalJournal of Clinical Pathology
    Publication statusPublished - 13 Jan 2016


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