Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers

M Mian; Mairead Mcnamara; M Doherty; D Hedley; JJ Knox; S Serra

Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers

M Mian, Mairead Mcnamara, M Doherty, D Hedley, JJ Knox, S Serra

Research output: Contribution to journal › Article › peer-review

Abstract

AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC). METHODS: Expressions of ERCC1 and XRCC1 were determined by immunohistochemistry (IHC) for 160 patients with BTC and association with clinicopathological features and patient survival was performed to evaluate their predictive and prognostic values. RESULTS: Neoplastic tissue showed much lower nuclear expression compared with non-neoplastic tissue for ERCC1 (median immunostaining score (IS)=0.7 (95% CI 0.2 to 1.3) vs 8.0 (95% CI 5.5 to 8.0), p

Original language	English
Journal	Journal of Clinical Pathology
Publication status	Published - 13 Jan 2016

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title = "Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers",

abstract = "AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC). METHODS: Expressions of ERCC1 and XRCC1 were determined by immunohistochemistry (IHC) for 160 patients with BTC and association with clinicopathological features and patient survival was performed to evaluate their predictive and prognostic values. RESULTS: Neoplastic tissue showed much lower nuclear expression compared with non-neoplastic tissue for ERCC1 (median immunostaining score (IS)=0.7 (95% CI 0.2 to 1.3) vs 8.0 (95% CI 5.5 to 8.0), p",

author = "M Mian and Mairead Mcnamara and M Doherty and D Hedley and JJ Knox and S Serra",

year = "2016",

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day = "13",

language = "English",

journal = "Journal of Clinical Pathology",

issn = "0021-9746",

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TY - JOUR

T1 - Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers

AU - Mian, M

AU - Mcnamara, Mairead

AU - Doherty, M

AU - Hedley, D

AU - Knox, JJ

AU - Serra, S

PY - 2016/1/13

Y1 - 2016/1/13

N2 - AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC). METHODS: Expressions of ERCC1 and XRCC1 were determined by immunohistochemistry (IHC) for 160 patients with BTC and association with clinicopathological features and patient survival was performed to evaluate their predictive and prognostic values. RESULTS: Neoplastic tissue showed much lower nuclear expression compared with non-neoplastic tissue for ERCC1 (median immunostaining score (IS)=0.7 (95% CI 0.2 to 1.3) vs 8.0 (95% CI 5.5 to 8.0), p

AB - AIMS: To investigate the predictive and prognostic values of DNA repair genes excision repair cross-complementation group 1 (ERCC1) and X-ray repair cross-complementing group 1 (XRCC1) in tumour samples from patients with a diagnosis of biliary tract cancer (BTC). METHODS: Expressions of ERCC1 and XRCC1 were determined by immunohistochemistry (IHC) for 160 patients with BTC and association with clinicopathological features and patient survival was performed to evaluate their predictive and prognostic values. RESULTS: Neoplastic tissue showed much lower nuclear expression compared with non-neoplastic tissue for ERCC1 (median immunostaining score (IS)=0.7 (95% CI 0.2 to 1.3) vs 8.0 (95% CI 5.5 to 8.0), p

M3 - Article

SN - 0021-9746

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

ER -

Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers

Abstract

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