Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).

Stefan Suciu; Natalie Ives; Alexander M. Eggermont; John M. Kirkwood; Paul Lorigan; Svetomir Markovic; Claus Garbe; Keith Wheatley

doi:10.1200/jco.2014.32.15_suppl.9067

Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).

Stefan Suciu, Natalie Ives, Alexander M. Eggermont, John M. Kirkwood, Paul Lorigan, Svetomir Markovic, Claus Garbe, Keith Wheatley

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

9067 Background: Many randomised trials have evaluated the role of adjuvant IFN in high-risk melanoma, some suggesting benefit and others not. To assess the evidence of IFN vs. no IFN, an IPD meta-analysis of these trials was performed. Methods: Standard IPD meta-analysis methods were used to assess event-free (EFS) and overall survival (OS), with odds ratios (OR) and confidence intervals (CI) calculated. Trials were divided by dose of IFN - high (10-20MU/m2), Peg-IFN (3-6{micro}g/Kg), intermediate (5-10MU flat), low (3MU flat) and very low (1MU). Results: IPD was provided for 11 of 15 reported trials of IFN vs. no IFN (for the other 4 trials published data were used). Over 7500 pts were included in the analysis, with over 4700 and 3800 events for EFS and OS. There was benefit for IFN for both EFS (P

Original language	English
Pages (from-to)	9067-9067
Number of pages	1
Journal	Journal of Clinical Oncology
Volume	32
Issue number	15_suppl
DOIs	https://doi.org/10.1200/jco.2014.32.15_suppl.9067
Publication status	Published - 3 Jan 2019

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Manchester Cancer Research Centre

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10.1200/jco.2014.32.15_suppl.9067

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Suciu, S., Ives, N., Eggermont, A. M., Kirkwood, J. M., Lorigan, P., Markovic, S., Garbe, C., & Wheatley, K. (2019). Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts). Journal of Clinical Oncology, 32(15_suppl), 9067-9067. https://doi.org/10.1200/jco.2014.32.15_suppl.9067

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title = "Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).",

abstract = "9067 Background: Many randomised trials have evaluated the role of adjuvant IFN in high-risk melanoma, some suggesting benefit and others not. To assess the evidence of IFN vs. no IFN, an IPD meta-analysis of these trials was performed. Methods: Standard IPD meta-analysis methods were used to assess event-free (EFS) and overall survival (OS), with odds ratios (OR) and confidence intervals (CI) calculated. Trials were divided by dose of IFN - high (10-20MU/m2), Peg-IFN (3-6{micro}g/Kg), intermediate (5-10MU flat), low (3MU flat) and very low (1MU). Results: IPD was provided for 11 of 15 reported trials of IFN vs. no IFN (for the other 4 trials published data were used). Over 7500 pts were included in the analysis, with over 4700 and 3800 events for EFS and OS. There was benefit for IFN for both EFS (P",

author = "Stefan Suciu and Natalie Ives and Eggermont, {Alexander M.} and Kirkwood, {John M.} and Paul Lorigan and Svetomir Markovic and Claus Garbe and Keith Wheatley",

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doi = "10.1200/jco.2014.32.15_suppl.9067",

language = "English",

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Suciu, S, Ives, N, Eggermont, AM, Kirkwood, JM, Lorigan, P, Markovic, S, Garbe, C & Wheatley, K 2019, 'Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).', Journal of Clinical Oncology, vol. 32, no. 15_suppl, pp. 9067-9067. https://doi.org/10.1200/jco.2014.32.15_suppl.9067

Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts). / Suciu, Stefan; Ives, Natalie; Eggermont, Alexander M. et al.
In: Journal of Clinical Oncology, Vol. 32, No. 15_suppl, 03.01.2019, p. 9067-9067.

Research output: Contribution to journal › Meeting Abstract › peer-review

TY - JOUR

T1 - Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).

AU - Suciu, Stefan

AU - Ives, Natalie

AU - Eggermont, Alexander M.

AU - Kirkwood, John M.

AU - Lorigan, Paul

AU - Markovic, Svetomir

AU - Garbe, Claus

AU - Wheatley, Keith

PY - 2019/1/3

Y1 - 2019/1/3

N2 - 9067 Background: Many randomised trials have evaluated the role of adjuvant IFN in high-risk melanoma, some suggesting benefit and others not. To assess the evidence of IFN vs. no IFN, an IPD meta-analysis of these trials was performed. Methods: Standard IPD meta-analysis methods were used to assess event-free (EFS) and overall survival (OS), with odds ratios (OR) and confidence intervals (CI) calculated. Trials were divided by dose of IFN - high (10-20MU/m2), Peg-IFN (3-6{micro}g/Kg), intermediate (5-10MU flat), low (3MU flat) and very low (1MU). Results: IPD was provided for 11 of 15 reported trials of IFN vs. no IFN (for the other 4 trials published data were used). Over 7500 pts were included in the analysis, with over 4700 and 3800 events for EFS and OS. There was benefit for IFN for both EFS (P

AB - 9067 Background: Many randomised trials have evaluated the role of adjuvant IFN in high-risk melanoma, some suggesting benefit and others not. To assess the evidence of IFN vs. no IFN, an IPD meta-analysis of these trials was performed. Methods: Standard IPD meta-analysis methods were used to assess event-free (EFS) and overall survival (OS), with odds ratios (OR) and confidence intervals (CI) calculated. Trials were divided by dose of IFN - high (10-20MU/m2), Peg-IFN (3-6{micro}g/Kg), intermediate (5-10MU flat), low (3MU flat) and very low (1MU). Results: IPD was provided for 11 of 15 reported trials of IFN vs. no IFN (for the other 4 trials published data were used). Over 7500 pts were included in the analysis, with over 4700 and 3800 events for EFS and OS. There was benefit for IFN for both EFS (P

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M3 - Meeting Abstract

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EP - 9067

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 15_suppl

ER -

Suciu S, Ives N, Eggermont AM, Kirkwood JM, Lorigan P, Markovic S et al. Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts). Journal of Clinical Oncology. 2019 Jan 3;32(15_suppl):9067-9067. doi: 10.1200/jco.2014.32.15_suppl.9067

Predictive importance of ulceration on the efficacy of adjuvant interferon-a (IFN): An individual patient data (IPD) meta-analysis of 15 randomized trials in more than 7,500 melanoma patients (pts).

Abstract

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