Predictive values of serum tumour markers tetranectin, OVX1, CASA and CA125 in patients with a pelvic mass

Estrid V S Hgdall, Claus K. Høgdall, Solveig Tingulstad, Bjørn Hagen, Kjell Nustad, Feng Ji Xu, Robert C. Bast, Ian J. Jacobs

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Our objective was to compare the predictive value of the well-established tumour marker CA125 with the newer tumour markers tetranectin (TN), OVX1 and CASA in distinguishing benign and malignant pelvic masses in women. Participants included 185 women, 19 years or older, with a pelvic mass planned for surgical exploration. Significantly different CA125 levels were found between benign tumours and localised ovarian cancer (OC), advanced OC and other non-OCs. Significantly different TN levels were found between benign tumours and advanced OC (stage III/IV), between benign tumours and other cancers and between all OCs and other cancers. For CASA, significant differences were found between benign tumours and all OCs as well as advanced OC. No significant differences could be demonstrated for OVX1. Significant correlations for the 44 OC patients were found between CA125, TN and CASA. No significant correlations were found for OVX1, possibly because of the method used for collection and handling of serum samples. None of the new markers had any additional predictive value compared to CA125. TN and CASA levels correlated with FIGO stage and could be used to discriminate between benign and advanced OC. However, in comparison to the performance of CA 125, the additional discriminative value of TN and CASA was minor. (C) 2000 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)519-523
    Number of pages4
    JournalInternational Journal of Cancer
    Volume89
    Issue number6
    DOIs
    Publication statusPublished - 20 Nov 2000

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