Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas

A. H. Hajeer, J. T. Lear, W. E R Ollier, M. Naves, J. Worthington, D. A. Bell, A. G. Smith, W. P. Bowers, P. W. Jones, R. C. Strange, A. A. Fryer

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Tumour necrosis factor alpha (TNF-α) appears important in ultraviolet- induced immunosuppression, suggesting that it is a susceptibility candidate for cutaneous basal cell carcinoma (BCC). We now describe data on the association between TNF microsatellite polymorphisms, first on susceptibility in 202 controls and 133 cases each having two to 30 BCCs, and secondly, within the cases, on BCC numbers. The data show that the proportions of individuals with TNF a1- and a7-containing genotypes were significantly different (P = 0.0271, P = 0.0393, respectively) between cases and controls. Secondly, within the cases, TNF alleles d4 (P = 0.023) and d6 (P = 0.006) alone, and the TNF a2-b4-d5 haplotype (P = 0.007), were significantly associated with the number of BCC lesions. These preliminary data provide the first evidence that TNF microsatellite polymorphism may influence the pathogenesis of multiple BCC.
    Original languageEnglish
    Pages (from-to)441-445
    Number of pages4
    JournalBritish Journal of Dermatology
    Volume142
    Issue number3
    DOIs
    Publication statusPublished - 2000

    Keywords

    • Basal cell carcinoma
    • Genetic susceptibility
    • Haplotypes
    • Microsatellites
    • Polymorphism
    • Tumour necrosis factor

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