Prenatal programming of renal sodium handling in the rat

Saleh H. Alwasel, Nick Ashton

    Research output: Contribution to journalArticlepeer-review


    Prenatally programmed hypertension induced by maternal protein restriction is associated with increased expression of the renal tubular Na+/K+/2Cl- co-transporter (NKCC2) and the Na+/Cl- co-transporter (NCC). This has led to the suggestion that renal Na+ retention contributes to the development of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero). However, this hypothesis has not been tested in vivo. Renal clearance measurements in hypertensive 4-week-old male and female LP rats showed that, although the glomerular filtration rate remained unaltered, urine flow (P
    Original languageEnglish
    Pages (from-to)75-84
    Number of pages9
    JournalClinical Science
    Issue number2
    Publication statusPublished - 2009


    • Fetal programming
    • Kidney
    • Na+/K+/2Cl- co-transporter (NKCC2)
    • Pressure-natriuresis relationship
    • Sodium pump


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