Prenatal smoking exposure and asymmetric fetal growth restriction

Ali Delpisheh; Loretta Brabin; Sandra Drummond; Bernard J. Brabin

doi:10.1080/03014460802375596

Prenatal smoking exposure and asymmetric fetal growth restriction

Ali Delpisheh, Loretta Brabin, Sandra Drummond, Bernard J. Brabin

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Prenatal smoking exposure causes intrauterine fetal growth restriction (IUGR), although its effects on fetal proportionality are less clearly defined. Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure. Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out. Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p=0.002) than symmetric IUGR (p=0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p

Original language	English
Pages (from-to)	573-583
Number of pages	10
Journal	Annals of Human Biology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1080/03014460802375596
Publication status	Published - 1 Nov 2008

Keywords

Asymmetry
IUGR
Pregnancy
Smoking

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10.1080/03014460802375596

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title = "Prenatal smoking exposure and asymmetric fetal growth restriction",

abstract = "Background: Prenatal smoking exposure causes intrauterine fetal growth restriction (IUGR), although its effects on fetal proportionality are less clearly defined. Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure. Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out. Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p=0.002) than symmetric IUGR (p=0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p",

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T1 - Prenatal smoking exposure and asymmetric fetal growth restriction

AU - Delpisheh, Ali

AU - Brabin, Loretta

AU - Drummond, Sandra

AU - Brabin, Bernard J.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background: Prenatal smoking exposure causes intrauterine fetal growth restriction (IUGR), although its effects on fetal proportionality are less clearly defined. Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure. Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out. Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p=0.002) than symmetric IUGR (p=0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p

AB - Background: Prenatal smoking exposure causes intrauterine fetal growth restriction (IUGR), although its effects on fetal proportionality are less clearly defined. Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure. Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out. Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p=0.002) than symmetric IUGR (p=0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p

KW - Asymmetry

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KW - Pregnancy

KW - Smoking

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DO - 10.1080/03014460802375596

M3 - Article

SN - 0301-4460

VL - 35

SP - 573

EP - 583

JO - Annals of Human Biology

JF - Annals of Human Biology

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Prenatal smoking exposure and asymmetric fetal growth restriction

Abstract

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