Preparation of nanogels with temperature-responsive core and pH-responsive arms by photo-cross-linking

Dirk Kuckling; Cong Duan Vo; Sebastian E. Wohlrab

doi:10.1021/la015758q

Preparation of nanogels with temperature-responsive core and pH-responsive arms by photo-cross-linking

Dirk Kuckling
, Cong Duan Vo
, Sebastian E. Wohlrab

Research output: Contribution to journal › Article › peer-review

Abstract

The preparation of temperature-responsive colloidal nanogels with a pH-responsive shell could be achieved by photo-cross-linking of poly(N-isopropylacrylamide) (PNIPAAm) graft terpolymers. The graft terpolymers were synthesized from NIPAAm, poly(2-vinylpyridine) (P2VP) macromonomers, and a chromophore monomer based on dimethylmaleimide (DMIAAm). The resulting solutions of nanogel with temperatureresponsive core and chemically bounded (P2VP) arms exhibited more stablility upon heating and low pH as compared to the corresponding PNIPAAm nanogels. A large transition of the average hydrodynamic diameter of the gels could be observed by increasing either the temperature above 32 °C or the pH above 5. It was also demonstated that it is possible to obtain a response to one stimulus without interfering with the other stimulus. Dynamic light scattering (DLS), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR) were used for characterization of the core-shell nanogels.

Original language	English
Pages (from-to)	4263-4269
Number of pages	6
Journal	Langmuir
Volume	18
Issue number	11
DOIs	https://doi.org/10.1021/la015758q
Publication status	Published - 28 May 2002

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title = "Preparation of nanogels with temperature-responsive core and pH-responsive arms by photo-cross-linking",

abstract = "The preparation of temperature-responsive colloidal nanogels with a pH-responsive shell could be achieved by photo-cross-linking of poly(N-isopropylacrylamide) (PNIPAAm) graft terpolymers. The graft terpolymers were synthesized from NIPAAm, poly(2-vinylpyridine) (P2VP) macromonomers, and a chromophore monomer based on dimethylmaleimide (DMIAAm). The resulting solutions of nanogel with temperatureresponsive core and chemically bounded (P2VP) arms exhibited more stablility upon heating and low pH as compared to the corresponding PNIPAAm nanogels. A large transition of the average hydrodynamic diameter of the gels could be observed by increasing either the temperature above 32 °C or the pH above 5. It was also demonstated that it is possible to obtain a response to one stimulus without interfering with the other stimulus. Dynamic light scattering (DLS), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR) were used for characterization of the core-shell nanogels.",

author = "Dirk Kuckling and Vo, \{Cong Duan\} and Wohlrab, \{Sebastian E.\}",

year = "2002",

month = may,

day = "28",

doi = "10.1021/la015758q",

language = "English",

volume = "18",

pages = "4263--4269",

journal = "Langmuir",

issn = "1520-5827",

publisher = "American Chemical Society",

number = "11",

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TY - JOUR

T1 - Preparation of nanogels with temperature-responsive core and pH-responsive arms by photo-cross-linking

AU - Kuckling, Dirk

AU - Vo, Cong Duan

AU - Wohlrab, Sebastian E.

PY - 2002/5/28

Y1 - 2002/5/28

N2 - The preparation of temperature-responsive colloidal nanogels with a pH-responsive shell could be achieved by photo-cross-linking of poly(N-isopropylacrylamide) (PNIPAAm) graft terpolymers. The graft terpolymers were synthesized from NIPAAm, poly(2-vinylpyridine) (P2VP) macromonomers, and a chromophore monomer based on dimethylmaleimide (DMIAAm). The resulting solutions of nanogel with temperatureresponsive core and chemically bounded (P2VP) arms exhibited more stablility upon heating and low pH as compared to the corresponding PNIPAAm nanogels. A large transition of the average hydrodynamic diameter of the gels could be observed by increasing either the temperature above 32 °C or the pH above 5. It was also demonstated that it is possible to obtain a response to one stimulus without interfering with the other stimulus. Dynamic light scattering (DLS), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR) were used for characterization of the core-shell nanogels.

AB - The preparation of temperature-responsive colloidal nanogels with a pH-responsive shell could be achieved by photo-cross-linking of poly(N-isopropylacrylamide) (PNIPAAm) graft terpolymers. The graft terpolymers were synthesized from NIPAAm, poly(2-vinylpyridine) (P2VP) macromonomers, and a chromophore monomer based on dimethylmaleimide (DMIAAm). The resulting solutions of nanogel with temperatureresponsive core and chemically bounded (P2VP) arms exhibited more stablility upon heating and low pH as compared to the corresponding PNIPAAm nanogels. A large transition of the average hydrodynamic diameter of the gels could be observed by increasing either the temperature above 32 °C or the pH above 5. It was also demonstated that it is possible to obtain a response to one stimulus without interfering with the other stimulus. Dynamic light scattering (DLS), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR) were used for characterization of the core-shell nanogels.

U2 - 10.1021/la015758q

DO - 10.1021/la015758q

M3 - Article

SN - 1520-5827

VL - 18

SP - 4263

EP - 4269

JO - Langmuir

JF - Langmuir

IS - 11

ER -

Preparation of nanogels with temperature-responsive core and pH-responsive arms by photo-cross-linking

Abstract

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