Preparation of the silk fibroin 3D scaffolds with large pore sizes and high interconnectivity

Jun Song, Xiao Qin Wang, Jia Shen Li

Research output: Contribution to conferencePaperpeer-review


Silk fibroin (SF) has a variety of applications in biomedical science. Considering the contradiction between suitable pore size and outstanding mechanical properties, the paper focused on the topic of preparing the 3D scaffolds with large pore sizes and high interconnectivity. The porous scaffolds were prepared by using two methods including a combination of the freeze-drying and paraffin spheres leaching techniques and a combination of the air-dried and salt (NaCl or Na2CO3) leaching methods. To remove three porogen agents from the scaffolds, three different methods, i.e., washing by water, chemical reaction and soaking by organic solvent, were selected and tested in the study. After freeze-drying, silk scaffolds with different pore sizes and porosities were obtained. The properties of the prepared 3D scaffolds were evaluated in terms of morphology by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR) spectra, porosity and mechanical properties. The best porosity of the prepared sample reached up to 93%.

Original languageEnglish
Number of pages12
Publication statusPublished - 28 Jul 2018
Event11th Textile Bioengineering and Informatics Symposium - Manchester, United Kingdom
Duration: 25 Jul 201828 Jul 2018


Conference11th Textile Bioengineering and Informatics Symposium
Abbreviated titleTBIS 2018
Country/TerritoryUnited Kingdom


  • Paraffin spheres
  • Porous scaffold
  • Silk fibroin
  • Tissue engineering


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