Preservation and stability of cell therapy products: Recommendations from an expert workshop

Glyn N. Stacey; Che J. Connon; Karen Coopman; Alan J. Dickson; Barry Fuller; Charles J. Hunt; Paul Kemp; Julie Kerby; Jennifer Man; Paul Matejtschuk; Harry Moore; John Morris; Richard O.C. Oreffo; Nigel Slater; Stephen Ward; Claire Wiggins; Heiko Zimmermann

doi:10.2217/rme-2017-0073

Preservation and stability of cell therapy products: Recommendations from an expert workshop

Glyn N. Stacey^*, Che J. Connon, Karen Coopman, Alan J. Dickson, Barry Fuller, Charles J. Hunt, Paul Kemp, Julie Kerby, Jennifer Man, Paul Matejtschuk, Harry Moore, John Morris, Richard O.C. Oreffo, Nigel Slater, Stephen Ward, Claire Wiggins, Heiko Zimmermann

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures. This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies.

Original language	English
Pages (from-to)	553-564
Number of pages	12
Journal	Regenerative Medicine
Volume	12
Issue number	5
Early online date	19 Jul 2017
DOIs	https://doi.org/10.2217/rme-2017-0073
Publication status	Published - 2017

Keywords

Cell therapy
Cold-chain
Cryostorage
Preservation
Regenerative medicine
Stability
Vitrification

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.2217/rme-2017-0073

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Stacey, G. N., Connon, C. J., Coopman, K., Dickson, A. J., Fuller, B., Hunt, C. J., Kemp, P., Kerby, J., Man, J., Matejtschuk, P., Moore, H., Morris, J., Oreffo, R. O. C., Slater, N., Ward, S., Wiggins, C., & Zimmermann, H. (2017). Preservation and stability of cell therapy products: Recommendations from an expert workshop. Regenerative Medicine, 12(5), 553-564. https://doi.org/10.2217/rme-2017-0073

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title = "Preservation and stability of cell therapy products: Recommendations from an expert workshop",

abstract = "If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures. This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies.",

keywords = "Cell therapy, Cold-chain, Cryostorage, Preservation, Regenerative medicine, Stability, Vitrification",

author = "Stacey, {Glyn N.} and Connon, {Che J.} and Karen Coopman and Dickson, {Alan J.} and Barry Fuller and Hunt, {Charles J.} and Paul Kemp and Julie Kerby and Jennifer Man and Paul Matejtschuk and Harry Moore and John Morris and Oreffo, {Richard O.C.} and Nigel Slater and Stephen Ward and Claire Wiggins and Heiko Zimmermann",

year = "2017",

doi = "10.2217/rme-2017-0073",

language = "English",

volume = "12",

pages = "553--564",

journal = "Regenerative Medicine",

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publisher = "Taylor & Francis",

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Stacey, GN, Connon, CJ, Coopman, K, Dickson, AJ, Fuller, B, Hunt, CJ, Kemp, P, Kerby, J, Man, J, Matejtschuk, P, Moore, H, Morris, J, Oreffo, ROC, Slater, N, Ward, S, Wiggins, C & Zimmermann, H 2017, 'Preservation and stability of cell therapy products: Recommendations from an expert workshop', Regenerative Medicine, vol. 12, no. 5, pp. 553-564. https://doi.org/10.2217/rme-2017-0073

TY - JOUR

T1 - Preservation and stability of cell therapy products

T2 - Recommendations from an expert workshop

AU - Stacey, Glyn N.

AU - Connon, Che J.

AU - Coopman, Karen

AU - Dickson, Alan J.

AU - Fuller, Barry

AU - Hunt, Charles J.

AU - Kemp, Paul

AU - Kerby, Julie

AU - Man, Jennifer

AU - Matejtschuk, Paul

AU - Moore, Harry

AU - Morris, John

AU - Oreffo, Richard O.C.

AU - Slater, Nigel

AU - Ward, Stephen

AU - Wiggins, Claire

AU - Zimmermann, Heiko

PY - 2017

Y1 - 2017

N2 - If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures. This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies.

AB - If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures. This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies.

KW - Cell therapy

KW - Cold-chain

KW - Cryostorage

KW - Preservation

KW - Regenerative medicine

KW - Stability

KW - Vitrification

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DO - 10.2217/rme-2017-0073

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JO - Regenerative Medicine

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Preservation and stability of cell therapy products: Recommendations from an expert workshop

Abstract

Keywords

Research Beacons, Institutes and Platforms

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