Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma

Maurits N C de Koning, Sönke Jan Weissenborn, Jan Nico Bouwes Bavinck, Sylvie Euvrard, Adele C. Green, Catherine A. Harwood, Charlotte M. Proby, Wim G V Quint, Francesca Sampogna, Jan ter Schegget, Linda Struijk, Ulrike Wieland, Mariet C W Feltkamp, Y. G L de Graaf, E. J. Uphoff-Meijerink, L. E. Vos, R. Willemze, P. van der Zwan-Kralt, P. Z. van der Meijden, E. I. PlasmeijerP. Wanningen, R. Wolterbeek, A. C. Butnaru, A. Claudy, J. Kanitakis, T. Forschner, I. Nindl, E. Stockfleth, L. Naldi, A. Pizzagalli, F. Sassi, G. Tessari, J. Breuer, C. A. Harwood, S. R. Lambert, L. Mitchell, C. M. Proby, K. Purdie, H. Ran, H. Pfister, S. J. Weissenborn, K. Michael, M. Pawlita, P. Sehr, T. Waterboer, L. J. van Doorn, B. Kleter, M. N C de Koning, W. G V Quint, J. Ter Schegget, D. Abeni, C. Deppermann Fortes, T. J. Mannooranparampil, C. Masini, N. Melo-Salcedo, G. P Petasecca Donati, S. Simoni, A. C. Green, K. A. Mallitt, R. Neale, C. Olsen, P. O'Rourke, P. Buttner, S. Harrison

    Research output: Contribution to journalArticlepeer-review


    Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n5845) and immunosuppressed (n5560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UVirradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91% in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not. © 2009 SGM.
    Original languageEnglish
    Pages (from-to)1611-1621
    Number of pages10
    JournalJournal of General Virology
    Issue number7
    Publication statusPublished - 2009


    Dive into the research topics of 'Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma'. Together they form a unique fingerprint.

    Cite this