Abstract
Objective
To estimate prevalence of major cardiovascular events among people with schizophrenia who had experience of sleep disturbance, sedentary behavior or muscular weakness, and assess evidence for raised prevalence in these individuals compared to people with schizophrenia without these characteristics.
Methods
UK Biobank data on individuals diagnosed with schizophrenia (n=1544) were used to examine the prevalence of major cardiovascular events, specifically myocardial infarction, stroke, heart failure and cardiovascular death, among participants with candidate risk factors. Generalized linear models were fitted to estimate prevalence ratios (PRs) for major cardiovascular events among participants with self-reported sleep disturbance, self-reported sedentary behavior and muscular weakness measured using a handgrip dynamometer. These ratios were adjusted for QRISK®3 score - a validated cardiovascular risk prediction algorithm for the UK population.
Results
Prevalence of major cardiovascular events was significantly higher among participants with daytime sleepiness, independent of QRISK®3 score, and snoring, a proxy for sleep-disordered breathing (adjusted PR 1.26; 95% CI 1.03, 1.55, p=0.03). Prevalence was also independently higher among participants with low muscular strength (adjusted PR1.36; 95% CI 1.05, 1.75, p=0.02). The adjusted prevalence ratios among participants with short or prolonged sleep duration, insomnia or sedentary behavior did not indicate independently raised prevalence among these groups.
Conclusion
Prevalence of major cardiovascular events among people with schizophrenia was higher in participants with muscular weakness and sleep disturbance evidenced by daytime sleepiness. Further research is required to determine how these factors can be routinely identified and addressed in the clinical management of cardiovascular risk among patients with schizophrenia.
To estimate prevalence of major cardiovascular events among people with schizophrenia who had experience of sleep disturbance, sedentary behavior or muscular weakness, and assess evidence for raised prevalence in these individuals compared to people with schizophrenia without these characteristics.
Methods
UK Biobank data on individuals diagnosed with schizophrenia (n=1544) were used to examine the prevalence of major cardiovascular events, specifically myocardial infarction, stroke, heart failure and cardiovascular death, among participants with candidate risk factors. Generalized linear models were fitted to estimate prevalence ratios (PRs) for major cardiovascular events among participants with self-reported sleep disturbance, self-reported sedentary behavior and muscular weakness measured using a handgrip dynamometer. These ratios were adjusted for QRISK®3 score - a validated cardiovascular risk prediction algorithm for the UK population.
Results
Prevalence of major cardiovascular events was significantly higher among participants with daytime sleepiness, independent of QRISK®3 score, and snoring, a proxy for sleep-disordered breathing (adjusted PR 1.26; 95% CI 1.03, 1.55, p=0.03). Prevalence was also independently higher among participants with low muscular strength (adjusted PR1.36; 95% CI 1.05, 1.75, p=0.02). The adjusted prevalence ratios among participants with short or prolonged sleep duration, insomnia or sedentary behavior did not indicate independently raised prevalence among these groups.
Conclusion
Prevalence of major cardiovascular events among people with schizophrenia was higher in participants with muscular weakness and sleep disturbance evidenced by daytime sleepiness. Further research is required to determine how these factors can be routinely identified and addressed in the clinical management of cardiovascular risk among patients with schizophrenia.
Original language | English |
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Journal | Schizophrenia Bulletin Open |
DOIs | |
Publication status | Published - 19 Jan 2021 |